Complete Genome Sequence of Bifidobacterium angulatum GT102: Potential Genes and Systems of Communication with Host

Abstract

We carried out the full genome sequencing of Bifidobacterium angulatum GT102. B. angulatum is rare species in the human gut microbiota, compared to the Bifidobacterium longum and Bifidobacterium adolescentis. In this regard, we investigated the genes of B. angulatum GT102 that are supposedly involved in the interaction with the host. Our analysis revealed an interesting histidine kinase HK10 belonging to the family of kinases, which can be bacterial adrenergic receptors. We discovered the PFNA cluster comprising a gene encoding fibronectin type III domain-containing protein having cytokine receptor motifs. The products of this cluster are possibly capable of interacting with human cytokines. Moreover genome of B. angulatum GT102 contains gene cluster, involved in the production of cell surface-associated capsular exopolysaccharides, that has unique genetic structure. The obtained results provided information regarding some undescribed characteristics of B. angulatum species and also help to better understand in a comparative aspect its communication characteristics.