TRANSIENT NEUROLOGICAL DEFICIT IN NEURAL AMYOTROPHY OF CHARCOT-MARIE-TOOTH: CLINICAL OBSERVATION AND LITERATURE REVIEW


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Abstract

Some acute transient insult-like episodes can occur in patients with Charcot-Marie-Tooth X-type disease, mainly in childhood and adolescence. Their development is probably associated with leukoencephalopathy due to the mutation of the GJB1 gene, which is observed in both peripheral and central nervous system. Acute neurologic symptoms with MRI-verified leukoencephalopathy can be wrongly supposed to the incorrect diagnosis, acute disseminated encephalomyelitis for example. Such patients can get unnecessary examinations and potentially dangerous treatment. We present a clinical case of the 19-year-old patient with CMTX, who entered neurology department of Republican Clinical Hospital in Kazan city after the development of two transient insult-like episodes with the following manifestations: hemiparesis, dysarthria, dysphagia with MRT-revealed white matter lesions of the brain.

About the authors

Aydar N Khabibrakhmanov

Kazan state medical university

Email: aidarxah@mail.com
department of neurology and rehabilitation 420012, Kazan, Butlerov Str., 49

Rezeda I Davleshina

Republican clinical hospital

department of neurology №1 420064, Kazan, Orenburgsky tract, 138, corp. A

Marat A Khayrullov

Republican clinical hospital

department of neurology №1 420064, Kazan, Orenburgsky tract, 138, corp. A

Enver I Bogdanov

Kazan state medical university

department of neurology and rehabilitation 420012, Kazan, Butlerov Str., 49

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Copyright (c) 2018 Khabibrakhmanov A.N., Davleshina R.I., Khayrullov M.A., Bogdanov E.I.

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