W. Einthoven. About nerve stimulation (through frequent alternating currents - Pflüger’s archive, vol. 82 p. 101, 1900. On irritation of nerves by frequent alternating currents

Abstract

It is known that electric current with increasing frequency of interruptions is more and more strong irritant for motor nerves; but this phenomenon is observed only until the attainment of a known, definite number of interruptions; with further increase, the effect does not increase, it reaches its maximum value; if the increase in frequency goes even further, then the effect of irritation begins to weaken, from which it follows that the excitability of the nerves for such currents begins to decrease.

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