Enviar artigo por via de e-mail The Role of TNF-α, TNFRSF1A, and CD40 Genes Polymorfisms in Multiple Sclerosis in Tomsk Region
- Autores: Titova M.A.1, Alifirova V.M.1, Musina N.F.1, Nikolaeva T.N.2
-
Afiliações:
- Siberian State Medical University, Neurology and Neurosurgery Department
- Siberian State Medical University, Neurology Clinic
- Edição: Volume 40, Nº 3 (2023)
- Páginas: 292-298
- Seção: Clinical Neurochemistry
- URL: https://journal-vniispk.ru/1027-8133/article/view/140529
- DOI: https://doi.org/10.31857/S1027813323020152
- EDN: https://elibrary.ru/UDCNUJ
- ID: 140529
Citar
Acesso aberto
Acesso está concedido
Somente assinantes
Resumo
We studied the role of polymorphisms rs1800629 of the TNF-α gene; rs4149584 of the TNFRSF1A gene; rs6074022, rs1883832, rs1535045, rs11086996 of the CD40 gene in the onset, clinical course and response to treatment in multiple sclerosis (MS) in a group of 152 patients, living in Tomsk region. 707 volunteers without autoimmune diseases and pathology of the nervous system were included in control group. The allele C of the rs6074022 polymorphism of CD40 gene was associated with the risk of MS and contributed to the high rate of disease progression. The T allele of the rs6074022 polymorphism of CD40 gene showed a significant association with the average rate of disease progression, and the GA genotype of rs1800629 polymorphism of TNF-α gene was associated with a higher frequency of MS exacerbations. Other polymorphisms did not demonstrate an association with both the risk of disease, the clinical features and response to treatment.
Palavras-chave
Sobre autores
M. Titova
Siberian State Medical University, Neurology and Neurosurgery Department
Email: nchjournal@gmail.com
Russia, Tomsk
V. Alifirova
Siberian State Medical University, Neurology and Neurosurgery Department
Email: nchjournal@gmail.com
Russia, Tomsk
N. Musina
Siberian State Medical University, Neurology and Neurosurgery Department
Email: nchjournal@gmail.com
Russia, Tomsk
T. Nikolaeva
Siberian State Medical University, Neurology Clinic
Email: nchjournal@gmail.com
Russia, Tomsk
Bibliografia
- Baranzini S.E., Oksenberg J.R. // Trends Genet. 2017. V. 33. № 12. P. 960–970.
- Alfredsson L., Olsson T. // Cold Spring Harb. Perspect. Med. 2019. V. 9. № 4. P. a028944.
- International Multiple Sclerosis Genetics Consortium, Hafler D.A., Compston A., Sawcer S., Lander E.S., Daly M.J., De Jager P.L., De Bakker P.I., Gabriel S.B., Mirel D.B., Ivinson A.J., Pericak-Vance M.A., Gregory S.G., Rioux J.D., McCauley J.L., Haines J.L., Barcellos L.F., Cree B., Oksenberg J.R., Hauser S.L. // N. Engl. J. Med. 2007. V. 357. № 9. P. 851–862.
- Dashti M., Ateyah K., Alroughani R., Al-Temaimi R. // Sci. Rep. 2020. V. 10. № 1. P. 7327.
- Cree B.A. // Handb. Clin. Neurol. 2014. V. 122. P. 193–209.
- Didonna A., Oksenberg J.R. // Clin. Chim. Acta. 2015. V. 449. P. 16–22.
- Nedwin G.E., Naylor S.L., Sakaguchi A.Y., Smith D., Jarrett-Nedwin J., Pennica D., Goeddel D.V., Gray P.W. // Nucleic. Acids. Res. 1985. V. 13. № 17. P. 6361–6373.
- Braun N., Michel U., Ernst B.P., Metzner R., Bitsch A., Weber F., Rieckmann P. // Neurosci. Lett. 1996. V. 215. № 2. P. 75–78.
- Grigorova A.A., Trenova A.G., Stanilova S.A. // Neurol. Res. 2021. V. 43. № 4. P. 291–298.
- Trenova A.G., Miteva L.D., Stanilova S.A. // J. Neuroimmunol. 2020. V. 347. P. 577357.
- Bakr N.M., Hashim N.A., El-Baz H.A.E., Khalaf E.M., Elharoun A.S. // Mult. Scler. Relat. Disord. 2021. V. 47. P. 102654.
- De Jager P.L., Jia X., Wang J., De Bakker P.I., Ottoboni L., Aggarwal N.T., Piccio L., Raychaudhuri S., Tran D., Aubin C., Briskin R., Romano S., International MS Genetics Consortium, Baranzini S.E., McCauley J.L., Pericak-Vance M.A., Haines J.L., Gibson R.A., Naeglin Y., Uitdehaag B., Matthews P.M., Kappos L., Polman C., McArdle W.L., Strachan D.P., Evans D., Cross A.H., Daly M.J., Compston A., Sawcer S.J., Weiner H.L., Hauser S.L., Hafler D.A., Oksenberg J.R. // Nat. Genet. 2009. V. 41. № 7. P. 776–782.
- Agulló L., Malhotra S., Fissolo N., Montalban X., Comabella M. // J. Neuroimmunol. 2015. V. 289. P. 12–20.
- Caminero A., Comabella M., Montalban X. // Clin. Exp. Immunol. 2011. V. 166. № 3. P. 338–345.
- Fadul C.E., Mao-Draayer Y., Ryan K.A., Noelle R.J., Wishart H.A., Channon J.Y., Kasper I.R., Oliver B., Mielcarz D.W., Kasper L.H. // Neurol. Neuroimmunol. Neuroinflamm. 2021. V. 8. № 6. P. e1096.
- Australia and New Zealand Multiple Sclerosis Genetics Consortium (ANZgene) //Nat. Genet. 2009. V. 41. № 7. P. 824–828.
- Al-Eitan L., Qudah M.A., Qawasmeh M.A. // Biomolecules. 2020. V. 10. № 3. P. 356.
- Sokolova E.A., Malkova N.A., Korobko D.S., Rozhdestvenskii A.S., Kakulya A.V., Khanokh E.V., Delov R.A., Platonov F.A., Popova T.Y., Aref’eva E.G., Zagorskaya N.N., Alifirova V.M., Titova M.A., Smagina I.V., El’chaninova S.A., Popovtseva A.V., Puzyrev V.P., Kulakova O.G., Tsareva E.Y., Favorova O.O., Shchur S.G., Lashch N.Y., Popova N.F., Popova E.V., Gusev E.I., Boyko A.N., Aulchenko Y.S., Filipenko M.L. // PLoS One. 2013. V. 8. № 4. P. e61032.
- International Multiple Sclerosis Genetics Consortium. // Science. 2019. V. 365. № 6460. P. eaav7188.
- Thompson A.J., Banwell B.L., Barkhof F., Carroll W.M., Coetzee T., Comi G., Correale J., Fazekas F., Filippi M., Freedman M.S., Fujihara K., Galetta S.L., Hartung H.P., Kappos L., Lublin F.D., Marrie R.A., Miller A.E., Miller D.H., Montalban X., Mowry E.M., Sorensen P.S., Tintoré M., Traboulsee A.L., Trojano M., Uitdehaag B.M.J., Vukusic S., Waubant E., Weinshenker B.G., Reingold S.C., Cohen J.A. // Lancet Neurol. 2018. V. 17. № 2. P. 162–173.
- Pandit L. // Ann. Indian. Acad. Neurol. 2019. V. 22. № 3. P. 261.
- Коробко Д.С., Малкова Н.А., Булатова Е.В., Бабенко Л.А., Сазонов Д.В., Соколова Е.А., Филипенко М.Л. // Журнал неврологии и психиатрии им. С.С. Корсакова. Спецвыпуски. 2013. Т. 113. № 2-2. С. 10–16.
- Смагина И.В., Ельчанинова С.А., Золовкина А.Г., Игнатова Ю.Н., Кудрявцева Е.А. // Журнал неврологии и психиатрии им. С.С. Корсакова. 2011. Т. 111. № 5. С. 42–45.
Arquivos suplementares
