ANALYSIS OF IMMUNOLOGICAL INDEXES AND EXTERNAL BREATH FUNCTION IN PATIENTS WITH BRONCHIAL ASTHMA UNDER THE TREATMENT WITH T-CELL IMMUNOTHERAPY AND STANDARD THERAPY
- Authors: Blinova E.A.1, Makarova A.E.1, Pashkina E.A.1, Demina D.V.1, Kozlov V.A.1
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Affiliations:
- Federal State Budgetary Scientific Institution «Research Institute of Fundamental and Clinical Immunology»
- Issue: Vol 22, No 2-1 (2019)
- Pages: 168-170
- Section: ORIGINAL ARTICLES
- URL: https://journal-vniispk.ru/1028-7221/article/view/119461
- DOI: https://doi.org/10.31857/S102872210006438-6
- ID: 119461
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Abstract
The study presents the clinical and immunological characteristics of patients with bronchial asthma, which had administrated with standard therapy and T-cell immunotherapy. After cell therapy, it was shown an improvement of external breath function, an increase in the number of CD8+ lymphocytes, a decrease in CD19+ cell subset, as well as a reducing of IgE level in the atopic form of the disease. All together it indicates the eff ectiveness of cell therapy. In patients with standard therapy, there was no change of investigated parameters in dynamics.
About the authors
E. A. Blinova
Federal State Budgetary Scientific Institution «Research Institute of Fundamental and Clinical Immunology»
Author for correspondence.
Email: blinovaelena-85@yandex.ru
PhD, senior researcher of the Laboratory of Clinical immunopathology,
Novosibirsk
Russian FederationA. E. Makarova
Federal State Budgetary Scientific Institution «Research Institute of Fundamental and Clinical Immunology»
Email: fake@neicon.ru
vaccinologist of Clinic of immunopathology,
Novosibirsk
Russian FederationE. A. Pashkina
Federal State Budgetary Scientific Institution «Research Institute of Fundamental and Clinical Immunology»
Email: fake@neicon.ru
PhD, researcher of the Laboratory of Clinical immunopathology,
Novosibirsk
Russian FederationD. V. Demina
Federal State Budgetary Scientific Institution «Research Institute of Fundamental and Clinical Immunology»
Email: fake@neicon.ru
Head of the allergology department of Clinical immunopathology,
Novosibirsk
Russian FederationV. A. Kozlov
Federal State Budgetary Scientific Institution «Research Institute of Fundamental and Clinical Immunology»
Email: fake@neicon.ru
academic RAS, M.D. D.S., Head of the Laboratory of Clinical immunopathology, scientific adviser,
Novosibirsk
Russian FederationReferences
- Global Strategy for Asthma Management and Prevention (GINA) 2015. – www.ginasthma.com.
- Патент RU № 2652752 C1. Блинова Е. А., Пашкина Е. А., Тевс А. Е., Непомнящих В. М., Леонова М. И., Демина Д. В., Козлов В. А. «Способ лечения бронхиальной астмы» // опубликован 28.04.2018 г. Бюллетень № 13.
- Скибо Ю. В., Курмаева Н. Ш., Цибулькина В. Н., Абрамова З. И. Структура основных популяций лимфоцитов у больных атопической бронхиальной астмой разной степени тяжести // Практическая медицина. 2012. – № 9 (65). – С. 154–158.
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