MUTATIONS IN THE GENES OF T-CELL RECEPTOR AND THE FUNCTIONAL STATE OF THE IMMUNE SYSTEM IN IRRADIATED PERSONS
- Authors: Akleyev A.A.1,2, Blinova E.A.2,3, Dolgushin I.I.1
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Affiliations:
- Southern-Urals State Medical University of the RF Ministry of Public Health
- Urals Research Center for Radiation Medicine of the FMBA of Russia
- Chelyabinsk State University
- Issue: Vol 20, No 3 (2017)
- Pages: 357-358
- Section: Articles
- URL: https://journal-vniispk.ru/1028-7221/article/view/119527
- ID: 119527
Cite item
Abstract
Among the exposed persons with elevated levels of TCR-mutations increase in levels of NK-CTL, activation of lysosomal activity of neutrophils, increase of serum ^-1α with depression of IL-2 and GM-CSF were observed.
Keywords
About the authors
A. A. Akleyev
Southern-Urals State Medical University of the RF Ministry of Public Health; Urals Research Center for Radiation Medicine of the FMBA of Russia
Author for correspondence.
Russian Federation
E. A. Blinova
Urals Research Center for Radiation Medicine of the FMBA of Russia; Chelyabinsk State UniversityRussian Federation
I. I. Dolgushin
Southern-Urals State Medical University of the RF Ministry of Public HealthRussian Federation
References
- I. ICRP Publication 118. Early and late effects of radiation in normal tissues and organs - threshold doses for tissue reactions in a radiation protection context. Annals of the ICRP. Elsevier. 2012, 322 p.
- Смирнова С. Г., Орлова Н. В., Замулаева И. А., Саенко А. С. Мутации по локусу Т-клеточного рецептора у людей в отдалённые сроки после острого и пролонгированного облучения. Радиационная биология. Радиоэкология. 2002, 42 (6), 624-627.
- Blinova E. A., Veremyeva G. A., Akleyev A. V. Apoptosis of peripheral blood lymphocytes and mutations in the gene of the T-cell receptor in survivors of chronic radiation exposure. Health Physics. 2012, V. 3, No. 1., 58-60.
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