POPULATION NK-CELLS IN PERIPHERAL BLOOD REFLECTS DELINEATED SPECIFIC PROCESSES IN PULMONARY TUBERCULOSIS
- Authors: Berdyugina O.V.1,2, Yershova A.V.1
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Affiliations:
- Ural Research Institute of Phthisiopulmonology
- Ural State Medical University
- Issue: Vol 20, No 3 (2017)
- Pages: 361-363
- Section: Articles
- URL: https://journal-vniispk.ru/1028-7221/article/view/119530
- ID: 119530
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Abstract
The purpose of the study was to examine the difference in the number of NK-cells in various forms of pulmonary tuberculosis. During the examined 124 people, of which 99 - have had a form of pulmonary tuberculosis, 25 - were practically healthy people. The study was performed by flow cytometry Coulter Epics XL (BeckmanCoulter, USA). Statistical analysis was performed with the use of programs Statistica for Windows v.6.1. It has been established that the presence of lung tuberculoma is associated with a decrease in the number of NK-cells compared to healthy people by 20 %. Reduced tuberculoma activity is accompanied by lowering of the agreed amount NK-cells by an average factor of two.
About the authors
O. V. Berdyugina
Ural Research Institute of Phthisiopulmonology; Ural State Medical University
Author for correspondence.
Email: noemail@neicon.ru
Russian Federation
A. V. Yershova
Ural Research Institute of Phthisiopulmonology
Email: noemail@neicon.ru
Russian Federation
References
- Seghatoleslam A., Hemmati M., Ebadat S. et al. Macrophage immune response suppression by recombinant Mycobacterium tuberculosis antigens, the ESAT-6, CFP-10, and ESAT-6/CFP-10 fusion proteins. Iranian Journal of Medical Sciences. 2016, 41(4), 296-304.
- Athman J. J., Sande O. J., GroftS. G. el al. Mycobacterium tuberculosis membrane vesicles inhibit T-cell activation. J. Immunol. 2017, 198(5), 2028-2037.
- Warren E., Teskey G., Venketaraman V. Effector mechanisms of neutrophils within the innate immune system in response to Mycobacterium tuberculosis infection. J. Clin. Med. 2017, 6 (15), 1-9.
- Zufferey C., Germano S., Dutta B. et al. The contribution of non-conventional T-cells and NK-cells in the mycobacterial-specific IFNy response in Bacil-leCalmette-Guerin-immunized infants. PloS One. 2013, 8(10), 1-9.
- Ramsugit S., Pillay M. Identification of Mycobacterium tuberculosis adherence-mediating components: a review of key methods to confirm adhesin function. Iranian Journal of Basic Medical Sciences. 2016, 19(6), 579-584.
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