FEATURES OF FORMATION OF THE MUCOSAL IMMUNITY OF THE UPPER RESPIRATORY TRACT IN PRETERM INFANTS IN THE FIRST YEAR OF LIFE
- Authors: Kalimullina A.R.1, Aznabaeva L.F.1, Amirova V.R.1
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Affiliations:
- Bashkir state medical University
- Issue: Vol 20, No 3 (2017)
- Pages: 381-383
- Section: Articles
- URL: https://journal-vniispk.ru/1028-7221/article/view/119555
- ID: 119555
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Abstract
Studied parameters of local immunity of the mucous membranes of the upper respiratory tract in 47 children the first year of life, born premature. Found that in preterm infants on nasal mucosa there is transient deficiency of IgG, low levels of IgE antibodies, cytokine IF-γ in the second half of life. These features of local immunity of the nasal mucosa is most pronounced in children born at gestational age of 28-32 weeks. The tension of mechanisms of the immune response in the mucosa of the oropharynx shows the excess production of proinflammatory cytokine IL-φ throughout the first year of life, and high IgE and IgA in the first half of the year.
About the authors
A. R. Kalimullina
Bashkir state medical University
Author for correspondence.
Email: noemail@neicon.ru
Russian Federation
L. F. Aznabaeva
Bashkir state medical University
Email: noemail@neicon.ru
Russian Federation
V. R. Amirova
Bashkir state medical University
Email: noemail@neicon.ru
Russian Federation
References
- Вельтищев Ю. Е. Иммунная недостаточность у детей. Российский вестник перинатологии и педиатрии 2004, 4, 4-10.
- Strunk T., Currie A., Richmond P., Simmer K., Burgner D. Innate immunity in human newborn infants: prematurity means more than immaturity. J. Matern Fetal Neonatal Med. 2011, 24, 25-31.
- Sharma A. A., Jen R., Butler A., Lavoie P. M. The developing human preterm neonatal immune system: a case for more research in this area. Clin. Immunol. 2012, 145, 61-68.
- Принципы этапного выхаживания недоношенных детей /Союз педиатров России, ФГБУ «Научный центр здоровья детей» РАМН; под ред. Л. С. Намазовой-Барановой.- Педиатрь, Москва 2013.- 240с.
- Sampalis J. S. Morbidity and mortality after RSV-associated hospitalizations among premature Canadian infants. J. Pediatr. 2003, 5, 150-156.
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