CROSS-LINKING ALLERGY IN BRONCHIAL ASTMA AND ALLERGEN-ASSOCIATED MOLECULAR PATTERNS (AAMP)

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Abstract

To evaluate content of IL-4 in lymphoblast transformation test (LTT) supernatants of 15 persons with asthma, 16 patients with asthma in association with allergy to prawns and 15 healthy persons were studied. All sufferers of asthma were sensibilisized to Der p 1 (Dermatophagoides pteronissinus). There have not been revealed any differences between the IL-4 in different groups that may be indirectly propose the presence of Allergen-Associated Molecular Patterns (AAMPs) in patients, which might smooth out received results.

About the authors

V. V. Klimov

Siberian State Medical University

Author for correspondence.
Russian Federation

V. S. Sviridova

Siberian State Medical University

Russian Federation

P. Yu. Isaev

Siberian State Medical University

Russian Federation

T. V. Koshovkina

Siberian State Medical University

Russian Federation

References

  1. Pali-Scholl I., Jensen-Jarolim E. The concept of allergen-associated molecular patterns (AAMP). Current Opinion in Immunology. 2016, 42,113-118.
  2. Treanor B. B-cell receptor: from resting state to activate. Immunology. 2012, 136:21-27.
  3. Deak P. E., Vrabel M. R., Pizzuti V. J., et al. Nanoallergens: A multivalent platform for studying and evaluating potency of allergen epitopes in cellular degranulation. Exp Biol Med (Maywood). 2016, 241,996-1006.
  4. Шкатова А. Н. Динамика содержания ИЛ-4 у больных микогенными респираторными ал-лергозами при проведение специфической иммунотерапии. Вестник СГМУ (Томск) 2000, 1, 2, 93-94.

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Copyright (c) 2017 Klimov V.V., Sviridova V.S., Isaev P.Y., Koshovkina T.V.

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