NATURE OF IMMUNE DISTURBANCES AND POSSIBILITY OF IMMUNOCORRECTION IN BURN DISEASE


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Abstract

An extended analysis of the immune status (more than 45 indicators) was carried out in 120 patients with a burn injury. The revealed statistically significant immune disorders are associated with parallel processes: immune hyperactivity and immunosuppression, the severity of which depends on the area of the burn injury and the period of the burn disease. Early immunodiagnostics according to the formula for prediction of sepsis developed by us, allows to identify patients with a high risk of generalization of infection and sepsis for the corresponding complex therapy and timely immunocorrection.

About the authors

M. N. Kozlova

A. V. Vishnevsky National Medical Research Center of Surgery

Author for correspondence.
Email: mnkozlova@rambler.ru

PhD, Senior Researcher, Clinical Immunology Group, Clinical Diagnostic Laboratory,

Moscow

Russian Federation

V. M. Zemskov

A. V. Vishnevsky National Medical Research Center of Surgery

MD, Professor, Chief Researcher, Head of the Clinical Immunology Group of the Clinical Diagnostic Laboratory,

Moscow

Russian Federation

A. A. Alekseev

A. V. Vishnevsky National Medical Research Center of Surgery

MD, PhD, Head of Burns Center,

Moscow

Russian Federation

N. S. Shishkinа

A. V. Vishnevsky National Medical Research Center of Surgery

Junior Researcher, Clinical Immunology Group, Clinical Diagnostic Laboratory,

Moscow

Russian Federation

A. A. Barsukov

A. V. Vishnevsky National Medical Research Center of Surgery

PhD, Senior Researcher, Clinical Immunology Group, Clinical Diagnostic Laboratory,

Moscow

Russian Federation

V. S. Demidovа

A. V. Vishnevsky National Medical Research Center of Surgery

Doctor of biological sciences, Head of the clinical diagnostic laboratory,

Moscow

Russian Federation

References

  1. Земсков В. М., Алексеев А. А., Козлова М. Н., Шишкина Н. С., Гнатенко Д. А., Земсков А. М., Бахов Н. И. Иммунная диагностика септических осложнений при ожогах. // Успехи современной биологии. – 2015. – Т. 135. № 6. – С. 531–541.
  2. Greenhalgh D. G. Sepsis in the burn patient: a diff erent problem than sepsis in the general population. // Burns Trauma. 2017; 5: 23.
  3. Zemskov V. M., Alekseev A. A., Gnatenko D. A., Kozlova M. N., Shishkina N. S., Zemskov A. M., Zhegalova I. V., Bleykhman D. A., Bahov N. I., Suchkov S. V. Composite Biomarker Panel as a Highly Informative and Reliable Tool for Predicting Septic Complications.//Jacobs Journal of Biomarkers – 2016. – Vol. 2(1): 016, p.1–10.
  4. V. M. Zemskov, A. A. Alekseev, M. N. Kozlova, N. S. Shishkina, D. A. Gnatenko, A. M. Zemskov and N. I. Bahov. Immune diagnostics of septic complications in burns. // Biology bulletin reviews. – 2016. – Vol. 6, No. 4, p. 344–354.
  5. Zemskov V. M., Alekseev A. A., Kozlova M. N., Shishkina N. S., Bleykhman D. A., Zemskov A. M., Suchkoiv S. V. Changes in the immune system depending on the stage of burn disease and the area of thermal destruction. Immunoglobin replacement therapy with gabriglobin. International Journal of Recent Scientific Research. Vol. 8, Issue, 1, pp. 15407–15412, January, 2017.

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Copyright (c) 2019 Kozlova M.N., Zemskov V.M., Alekseev A.A., Shishkinа N.S., Barsukov A.A., Demidovа V.S.

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