THE IMPORTANCE OF GENOTYPIC AND IMMUNOPHENOTYPIC CHARACTERISTICS IN THE PATHOGENESIS AND TREATMENT OF CHRONIC HCV-INFECTION
- 作者: Nabieva U.P.1, Ismailova A.A.1, Adylov D.G.1
-
隶属关系:
- Republican Scientific Center of Immunology of the Ministry of Health of the Republic of Uzbekistan
- 期: 卷 20, 编号 3 (2017)
- 页面: 435-439
- 栏目: Articles
- URL: https://journal-vniispk.ru/1028-7221/article/view/119651
- ID: 119651
如何引用文章
全文:
详细
The article is devoted to the investigation of the correspondence of the genotype of the IL-28B gene to the virological, biochemical and immunological parameters of patients with chronic viral hepatitis C in the course of antiviral therapy of pegylated interferon α and ribavirin. It was found that with the genotype of the CC gene of the IL-28B gene at the locus rsl2979860, in which the non-genotype of the hepatitis C virus was most often detected, self-healing and high efficacy of PVT are most often observed. On the part of the organism’s reactogenicity, this was accompanied by a more pronounced cytolytic syndrome and a high immunological reactivity of the organism, manifested in an increase in the expression of cytotoxic lymphocytes CD8+, activation markers CD23+ and CD38+.
作者简介
U. Nabieva
Republican Scientific Center of Immunology of the Ministry of Health of the Republic of Uzbekistan
编辑信件的主要联系方式.
Email: noemail@neicon.ru
俄罗斯联邦
A. Ismailova
Republican Scientific Center of Immunology of the Ministry of Health of the Republic of Uzbekistan
Email: noemail@neicon.ru
俄罗斯联邦
D. Adylov
Republican Scientific Center of Immunology of the Ministry of Health of the Republic of Uzbekistan
Email: noemail@neicon.ru
俄罗斯联邦
参考
- Ивашкин В. Т., Мамаев С. Н., Лукина Е. А. Особенности иммунного статуса у больных хроническим вирусным гепатитом С // Рос.журнал гастроэн., гепатол., колопроктол.- 2001.- № 3.-С. 24-29.
- Мицура В. М., Воропаев Е. В., Осипкина О. В., Жаворонок С. В. Полиморфизм генов интерлей-кина-28В и клиническое значение его выявления у пациентов с хроническим вирусным гепатитов С.// Лабораторная диагностика. -2012. -№ 2. -С. 86-97.
- Davis G. L. Early virologic response to treatment with peginterferon alfa-2b plus ribavirin in patients with chronic hepatitis С.// Hepatology.- 2003.-№ 38.- P. 645-652.
- Fellay D. Ge, J. et al. Genetic variation in IL28B predicts hepatitis С treatment-induced viral clearance. // J. Nature.- 2009.- Vol. 461.- P. 399-401.
- Fried M. W. et al. Peginterferon alfa-2a plus ribavirin for chronic hepatitis С virus infection / // N Engl J Med.- 2002.- Vol. 347.- P. 975-982.
- Ge D., Fellay J., Thompson AJ. et al. Genetic variation in IL28B predicts hepatitis C treatment-induced viral clearance. Nature. 2009 Sep 17; 461(7262): 399-401.
- Grebely J. et al. Potential role for lnterleukin-28B genotype in treatment decision-making in recent hepatitis С virus infection. // Hepatology - 2010.-Vol. 52.- P. 1216-1224.
- Lotrich F. E. et al. IL28B polymorphism is associated with both side effects and clearance of hepatitis С during interferon- alpha therapy.//Journal of Interferon & Cytokine Research.- 2011.- Vol. 31.-№ 3.- P. 331-336. Marc G. G. Diagnosis, management and treatment of hepatitis C. // Hepatology.- 2009.- Vol. 49.- P. 1335-1374.
- Ray Kim.W. Global epidemiology and burden of hepatitis C. Microbes.Infect. 4, 1219-1225 (2002).
- Rauch A. Genetic Variation in IL28B Is Associated With Chronic Hepatitis С and Treatment Failure: A Genome-Wide Association Study.// Gastroenterology.- 2010.- Vol. 138.- P. 1338-1345.
- Tanaka Y. et al. Genome-wide association of IL28B with response to pegylated interferon-alpha and ribavirin therapy for chronic hepatitis С.// Nat Genet.- 2009.- Vol. 41.- P. 1105-1109.
- Thompson AJ. et al. Interleukin-28B polymorphism improves viral kinetics and is the strongest pretreatment predictor of sustained virologic response in genotype 1 hepatitis С virus / // Gastroenterology.-2010.- Vol. 139.- P. 120-129.
补充文件
