EFFECT OF PREGNANCY-SPECIFIC β1-GLYCOPROTEIN ON CHEMOKINE PROFILE OF CULTURED T-HELPER AND MONONUCLEAR CELLS
- 作者: Zamorina S.A.1, Litvinova L.S.2, Yurova K.A.2, Khaziakhmatova O.G.2, Timganova V.P.1, Bochkova M.S.1, Khramtsov P.V.1,2, Rayev M.B.1
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隶属关系:
- Institute of Ecology and Genetics of Microorganisms UB RAS
- Immanuel Kant Baltic Federal University
- 期: 卷 22, 编号 2-1 (2019)
- 页面: 257-259
- 栏目: ORIGINAL ARTICLES
- URL: https://journal-vniispk.ru/1028-7221/article/view/119695
- DOI: https://doi.org/10.31857/S102872210006593-7
- ID: 119695
如何引用文章
全文:
详细
The effect of human pregnancy-specific β1-glycoprotein (PSG) on the production of chemokines by intact mononuclear cells and monocultures of CD4+ cells in vitro by Bio-Plex® multiplex immunoassay technology was studied. It has been established that PSG suppresses the production of IL-8, MIP-1α, MIP-1β, RANTES and MCP-1, chemokines, an elevated level of which is associated with spontaneous abortion. As a result, it can be concluded that PSG forms the fetoprotective chemokine profile of the studied immune cells.
作者简介
S. Zamorina
Institute of Ecology and Genetics of Microorganisms UB RAS
编辑信件的主要联系方式.
Email: mantissa7@mail.ru
PhD, MD (Biology), leading researcher,
Perm
俄罗斯联邦L. Litvinova
Immanuel Kant Baltic Federal University
PhD, MD (Medicine), Head, Basic Laboratory of Immunology and Cell Biotechnologies,
Kaliningrad
俄罗斯联邦K. Yurova
Immanuel Kant Baltic Federal University
PhD (Medicine), Researcher,
Kaliningrad
俄罗斯联邦O. Khaziakhmatova
Immanuel Kant Baltic Federal UniversityKaliningrad 俄罗斯联邦
V. Timganova
Institute of Ecology and Genetics of Microorganisms UB RAS
PhD, junior researcher,
Perm
俄罗斯联邦M. Bochkova
Institute of Ecology and Genetics of Microorganisms UB RAS
PhD, researcher,
Perm
俄罗斯联邦P. Khramtsov
Institute of Ecology and Genetics of Microorganisms UB RAS;Immanuel Kant Baltic Federal University
PhD, researcher, Perm;
researcher, Kaliningrad
俄罗斯联邦M. Rayev
Institute of Ecology and Genetics of Microorganisms UB RAS
PhD, MD, Leading Researcher,
Perm
俄罗斯联邦参考
- Du M.-R., Wang S. C., Li D. J. The integrative roles of chemokines at the maternal-fetal interface in early pregnancy // Cell. Mol. Immunol. 2014; 11(5): P. 438– 448.
- Раев М. Б. Способ выделения и очистки трофобластического β-1-гликопротеина. Патент РФ № 2367449 от 20.09.2009. / «Изобретения. Полезные модели». – 2009. – № 26.
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