THE ROLE OF THREE-DIMENSIONAL MATRICES IMITATING BONE TISSUE REGENERATION IN THE FORMATION OF HEMATOPOIETIC STEM CELLS POOL UNDER IN VITRO CULTIVATION CONDITIONS


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Abstract

The study is devoted to the search criteria for creating new bioresorbable materials that form hematopoietic stem cell niches that provide vascularization of regenerating bone tissue. In the experiment, it was revealed that the formation of hematopoietic stem cells pool under in vitro cultivation conditions depends on the surface roughness index of the artificial matrix.

About the authors

L. S. Litvinova

Immanuel Kant Baltic Federal University

Author for correspondence.

Doctor of Medical Science, Head of the Basic Laboratory of Immunology and Cell Biotechnologies,

Kaliningrad

Russian Federation

K. A. Yurova

Immanuel Kant Baltic Federal University

Email: kristina_kofanova@mail.ru

Ph.D., Researcher at the Base Laboratory of Immunology and Cell Biotechnology,

Kaliningrad

Russian Federation

V. V. Shupletsova

Immanuel Kant Baltic Federal University

Ph.D., Researcher at the Base Laboratory of Immunology and Cell Biotechnology,

Kaliningrad

Russian Federation

O. G. Khaziakhmatova

Immanuel Kant Baltic Federal University

Ph.D., Researcher at the Base Laboratory of Immunology and Cell Biotechnology,

Kaliningrad

Russian Federation

E. S. Melashchenko

Immanuel Kant Baltic Federal University

Biologist of the Center for Medical Biotechnology,

Kaliningrad

Russian Federation

V. V. Malashchenko

Immanuel Kant Baltic Federal University

Researcher, Center for Medical Biotechnologies,

Kaliningrad

Russian Federation

E. O. Shunkin

Immanuel Kant Baltic Federal University

Engineer Researcher Basic Laboratory of Immunology and Cell Biotechnology,

Kaliningrad

Russian Federation

Y. P. Sharkeev

Institute of Strength Physics and Materials Science SB RAS

Doctor of Physics and Mathematics, Professor, Head of Laboratory of Physics of nanostructured biocomposites,

Tomsk

Russian Federation

E. G. Komarova

Institute of Strength Physics and Materials Science SB RAS

Ph.D., Junior Researcher, Laboratory of Physics of Nanostructured Biocomposites,

Tomsk

Russian Federation

M. B. Sedelnikova

Institute of Strength Physics and Materials Science SB RAS

Doctor of Technical Science, Doctor of Technical Sciences Senior Researcher, Laboratory of Physics of Nanostructured Biocomposites,

Tomsk

Russian Federation

I. K. Norkin

Immanuel Kant Baltic Federal University

Ph.D., student,

Kaliningrad

Russian Federation

K. I. Prokin

Immanuel Kant Baltic Federal University

student,

Kaliningrad

Russian Federation

P. A. Ivanov

Immanuel Kant Baltic Federal University

Researcher at the Base Laboratory of Immunology and Cell Biotechnology,

Kaliningrad

Russian Federation

I. A. Khlusov

Siberian State Medical University

Ph.D., Professor of the Department of Morphology and General Pathology,

Tomsk

Russian Federation

References

  1. Dellatore S. M., Garcia A. S., Miller W. M. Mimicking stem cell niches to increase stem cell expansion //Current opinion in biotechnology, 2008, 19 (5), P. 534–540.

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Copyright (c) 2019 Litvinova L.S., Yurova K.A., Shupletsova V.V., Khaziakhmatova O.G., Melashchenko E.S., Malashchenko V.V., Shunkin E.O., Sharkeev Y.P., Komarova E.G., Sedelnikova M.B., Norkin I.K., Prokin K.I., Ivanov P.A., Khlusov I.A.

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