THE ATOPIC ASTHMA DISEASE COMPLICATED BY THE SMALL INTESTINE BACTERIAL OVERGROWTH (SIBO)
- Authors: Ivashkin V.T.1, Zolnikova O.Y.1
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Affiliations:
- Federal State Autonomous Educational Institution of Higher Education I. M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation
- Issue: Vol 22, No 2-1 (2019)
- Pages: 287-289
- Section: ORIGINAL ARTICLES
- URL: https://journal-vniispk.ru/1028-7221/article/view/119784
- DOI: https://doi.org/10.31857/S102872210006603-8
- ID: 119784
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Abstract
An efficacy of a gut microbiota control was investigated for the patients with atopic asthma. 45 patients with atopic asthma were included in the study. The results of our clinical and lab tests, PFTs, the lactulose hydrogen breath tests have been presented to evaluate SIBO. Under the standard SIBO’s therapy, the firrst group had being tested with Rifaximinum for the SIBO therapy during 7 days or Rifaximinum and with a succeeding probiotics therapy during 1 month. SIBO was diagnosed for 30 (67%) patients. We have detected the higher IgE level (p<0,01), the higher eosinophils level (р<0,001) in sputum and more significant decrease for FEV1 (р<0,01) in SIBO. The disorders correction of the intestinal microflora is accompanied the statistically significant decreasing of the immunological activity (p<0.01) and improvement of the external respiration function (p<0.001). So, SIBO is a significant factor aggravating the atopic asthma in patients.
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About the authors
V. T. Ivashkin
Federal State Autonomous Educational Institution of Higher Education I. M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation
Author for correspondence.
Email: fake@neicon.ru
MD, Academician of Russian Academy of Scienes. Head of the department of internal Diseases Propedeutics, Director of V. Vasilenko Clinic of internal diseases propedeutics, gastroenterology, and hepatology,
Moscow
Russian FederationO. Yu. Zolnikova
Federal State Autonomous Educational Institution of Higher Education I. M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation
Email: ks.med@mail.ru
associate professor of the department of internal Diseases Propedeutics,
Moscow
Russian FederationReferences
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