SEMAPHORIN 3A INHIBITS THYMOCYTE FUNCTIONS
- Authors: Rutto C.V.1, Starikova E.A.1, Lioudyno V.I.1, Kisseleva E.P.1,2
-
Affiliations:
- Institute for Experimental Medicine
- North-Western Medical Academy named after 1.1. Mechnikov
- Issue: Vol 20, No 3 (2017)
- Pages: 487-489
- Section: Articles
- URL: https://journal-vniispk.ru/1028-7221/article/view/119798
- ID: 119798
Cite item
Abstract
Semaphorin 3A (Sema 3A) is known to be an axon guidance molecule and is implicated in the development of nervous system. The aim of the study was to evaluate the influence of Sema 3A on functions of murine thymocytes, such as: proliferation, migration and adhesion to thymic epithelial cells. Sema 3A suppressed thymocyte proliferation at 100 and 200 ng/ml, possessed a chemorepellent activity towards thymocytes in the transwell system, and inhibited thymocyte adhesion to murine thymic epithelial cell lines cTEC 1-2 and mTEC 3-10. Thus, Sema 3A is a negative regulator of important thymocyte functions and may essentially affect the process of thymocyte maturation.
About the authors
C. V. Rutto
Institute for Experimental Medicine
Author for correspondence.
Russian Federation
E. A. Starikova
Institute for Experimental MedicineRussian Federation
V. I. Lioudyno
Institute for Experimental MedicineRussian Federation
E. P. Kisseleva
Institute for Experimental Medicine; North-Western Medical Academy named after 1.1. MechnikovRussian Federation
References
- Lepelletier Y., Smaniotto S., Hadj-Slimane R., Villa-Verde D. M. S., Nogueira A. C. et al. Control of human thymocyte migration by Neuropilin-1/ Semaphorin-3A-mediated interaction. Proc. Nat. Acad. Sci. USA. 2007, 104, 5545-5550.
- Kasai M., Hirokawa K., Kejino K., Ogasawara K., Tatsumi M. et al. Difference in antigen presentation pathways between cortical and medullary thymic epithelial cells. Eur. J. Immunol. 1996, 26, 2101-2107.
- Castellani V., Rougon G. Control of Semaphorin signaling. Curr. Opin. Neurobiol. 2002, 12, 532-541.
- Mendes-da-Cruz D.A., Lepelletier Y., Brignier A. C. et al. Neuropilins, semaphorins, and their role in thymocyte development Ann.N.Y.Acad.Sci. 2009, 1153, 20-28.
- Kim C. H., Pelus L. M., White J. R., Broxmeyer H. E. Differential chemotactic behavior of developing T cells in response to thymic chemokines. Blood 1998, 91,4434-4443.
Supplementary files
