MOLECULAR DIAGNOSTICS OF IGE REACTIVITY TO BIRCH POLLEN ALLERGENS IN CHILDREN WITH ALLERGIC RHINITIS

The aim of this study was to detect sIgE to isoallergens of birch pollen and to evaluate a contribution of some homologous food allergens to the development of sensibility in AR patients. There were 21 blood sera of AR patients and 20 blood sera of healthy persons without allergy symptoms. The total IgE levels and sIgE to allergens were measured by the ImmunoCAP method (Phadia, Sweden), as well as by the ELISA kits (Alkorbio, Russia). We detected high total IgE levels, sIgE to allergens of birch pollen, apple, celery, as well as to recombinant allergens of birch Bet v 1, Bet v 2 and soybean - Gly m 4 in AR patients. Correlation analysis showed the direct valid dependence between the sIgE levels to birch isoallergen Bet v 1 and soy isoallergen Gly m 4 (r=0,84; p<0,05). There was also the direct valid correlation between the sIgE levels to birch isoallergen Bet v 1 and allergens of apple and celery (r=0,67 and 0,57, accordingly). Our finding permits assert that cross-reactivity can be important in exacerbation of clinical symptoms in AR patients including progress of oral allergy syndrome.

аллергический ринит, sIgE к Bet v 1, Betv 2, Gly m 4, пищевые аллергены, латекс, allergic rhinitis, sIgE to Bet v 1, Bet v 2, Gly m 4, food allergens, latex