Features of the cytokine profile and relationships of polymorphisms of the immune system with levels of serum cytokines in individuals exposed to chronic radiation exposure
- Authors: Akleyev A..1,2, Blinova E..1,3, Kotikova A..1
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Affiliations:
- Urals Research Center for Radiation Medicine of the FMBA of Russia
- Southern-Urals State Medical University of the RF Ministry of Public Health
- Chelyabinsk State University
- Issue: Vol 21, No 3 (2018)
- Pages: 199-204
- Section: ORIGINAL ARTICLES
- URL: https://journal-vniispk.ru/1028-7221/article/view/119834
- DOI: https://doi.org/10.31857/S102872210002381-4
- ID: 119834
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Abstract
The article presents the results of the cytokine profi le study in Techa riverside residents exposed to chronic irradiation in diff erent periods of ontogenesis, as well as the relationship of the carrier polymorphic variants of genes IL1b, IL2, IL4, IL6, IL8 and TNFα with the content of the corresponding cytokines in the blood serum of irradiated persons. The decrease in the levels of pro-infl ammatory (IL-1β, IL-2, IL-6) and anti-infl ammatory (IL-4, IL-10) cytokines was noted in Techa riverside residents, whose period of intrauterine and childhood development fell out on the time of maximum radioactive discharges relative to groups of persons irradiated only in the postnatal period. Also, the connection of polymorphic rs1800872 gene IL10 with IL-10 content in blood serum was revealed.
Keywords
About the authors
A. . Akleyev
Urals Research Center for Radiation Medicine of the FMBA of Russia; Southern-Urals State Medical University of the RF Ministry of Public Health
Author for correspondence.
Email: noemail@neicon.ru
Russian Federation
E. . Blinova
Urals Research Center for Radiation Medicine of the FMBA of Russia; Chelyabinsk State University
Email: noemail@neicon.ru
Russian Federation
A. . Kotikova
Urals Research Center for Radiation Medicine of the FMBA of Russia
Email: noemail@neicon.ru
Russian Federation
References
- Evans C. H. Cytokines: molecular keys to homeostasis, development, and pathophysiology. J. Cell Biochem 1993, 53 (4), 277–279.
- Schaue D., Kachikwu E. L., McBride W. H. Cytokines in radiobiological responses: a review. Radiation research 2012, 176 (6), 505–523.
- Rastogi S., Coates P. J., Lorimore S. A., Wright E. G. Bystander-type eff ects mediated by long-lived infl ammatory signaling in irradiated bone marrow. Radiation Research. 2011, 177, 244–250.
- Schonfeld S., Krestinina L. Y., Epifanova S., Degteva M. O., Akleyev A. V., Preston D. L. Solid cancer mortality in the Techa River Cohort (1950–2007). Radiation Research. 2013, 179, 183–189.
- Krestinina, L.Y., Davis F. G., Schonfeld S., Preston D. L., Degteva M. O., Epifanova S., Akleyev A. V. Leukaemia incidence in the Techa River Cohort: 1953–2007. British Journal of Cancer. 2013, 109, 2886–2893.
- Кишкун А. А. Иммунологические исследования и методы диагностики инфекционных заболеваний в клинической практике. Медицинское информационное агентство, Москва 2009, 712 с.
- Реброва О. Ю. Статистический анализ медицинских данных. Применение пакета прикладных программ STATISTICA. Медиа Сфера, Москва 2002, 312 с.
- Sole X., Guino E., Valls J., Iniesta R., Moreno V. SNPStats: a web tool for the analysis of association studies. Bioinformatics. 2006, 22, 1928–1929.
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