Impact on ceruloplasmin on the chemiluminescence of neutrophils in chronic submaximal exercise capacity
- Authors: Ermolaeva E..1, Kantyukov S..1, Petuhova V..1, Surina-Marysheva E..2
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Affiliations:
- South Ural State Medical University
- South Ural State University (National Research University)
- Issue: Vol 21, No 3 (2018)
- Pages: 281-285
- Section: ORIGINAL ARTICLES
- URL: https://journal-vniispk.ru/1028-7221/article/view/119855
- DOI: https://doi.org/10.31857/S102872210002395-9
- ID: 119855
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Abstract
Exercise simulated in an experiment on 59 white rats. Chronic physical load submaximal power modeled daily swimming for 30 minutes. The load was increased gradually: the fi rst seven days, the animals swam every day without a load, the next two weeks the animals swam with a load of 2% of body weight. On 9, 15 and 21 day of the experiment, the animals were subjected to an additional maximum exertion: swam for 4 minutes with a load weight of 20% of body weight. Blood sampling was carried out on 9, 15 and 21 days after the experiment exercise intracardiac. Ceruloplasmin was administered on the 1st, 4th and 7th day of physical activity, in a total dose of 60 mg / kg of body weight. The intensity of free radical oxidation in whole blood was investigated by luminol-enhanced chemiluminescence. Under experimental conditions in rats, it was shown that in the case of chronic physical exercise of submaximal power, the production of free radicals in neutrophils decreases. The introduction of ceruloplasmin does not lead to a reduction in the reduced production of free radicals by neutrophilic leukocytes during physical activity.
About the authors
E. . Ermolaeva
South Ural State Medical University
Author for correspondence.
Email: noemail@neicon.ru
Russian Federation
S. . Kantyukov
South Ural State Medical University
Email: noemail@neicon.ru
Russian Federation
V. . Petuhova
South Ural State Medical University
Email: noemail@neicon.ru
Russian Federation
E. . Surina-Marysheva
South Ural State University (National Research University)
Email: noemail@neicon.ru
Russian Federation
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