THE ROLE OF NEUTROFILS IN THE PATHOGENESIS OF PREECLAMPSIA
- 作者: Kudryashova A.V.1, Panova I.A.1, Rokotyanskaya E.A.1
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隶属关系:
- Federal State Institution «Ivanovo Research Institute of Maternity and Childhood named after V. N. Gorodkova» the Ministry of Health of the Russian Federation
- 期: 卷 22, 编号 2-1 (2019)
- 页面: 350-352
- 栏目: ORIGINAL ARTICLES
- URL: https://journal-vniispk.ru/1028-7221/article/view/119949
- DOI: https://doi.org/10.31857/S102872210006624-1
- ID: 119949
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The aim of the work was to assess the nature of changes in the functional activity of neutrophils in women with preeclampsia and to identify their significance in the development of hypertension and proteinuria. For neutrophils of women with preeclampsia, the following were observed: increased levels of CD11b+, CD31+, CD49b, TLR4+, AnnexinV+PI+, IFNγ+, Granzyme B+, NBT-active cells, serum G-CSF, IL-8, IFNγ and Fractalkine; high level of MMP-9 synthesis; decreased levels of CD95+, CX3CR1+, CD62L+ and CD99+ cells. Correlation was noted between: the level of CD62L+, CD99+, CXCR1+ neutrophils, serum IL-8 and impaired elastic properties of blood vessels; CX3CR1+ neutrophil level and mean arterial pressure and proteinuria in a single portion of urine.
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作者简介
A. Kudryashova
Federal State Institution «Ivanovo Research Institute of Maternity and Childhood named after V. N. Gorodkova» the Ministry of Health of the Russian Federation
编辑信件的主要联系方式.
Email: niimid.immune@mail.ru
ВD, senior researcher of the laboratory of clinical immunology,
Ivanovo
俄罗斯联邦I. Panova
Federal State Institution «Ivanovo Research Institute of Maternity and Childhood named after V. N. Gorodkova» the Ministry of Health of the Russian Federation
Email: fake@neicon.ru
MD, assistant professor, head of Department of obstetrics and gynecology,
Ivanovo
俄罗斯联邦E. Rokotyanskaya
Federal State Institution «Ivanovo Research Institute of Maternity and Childhood named after V. N. Gorodkova» the Ministry of Health of the Russian Federation
Email: fake@neicon.ru
PhD, assistant Professor of the Department of Obstetrics and Gynecology,
Ivanovo
俄罗斯联邦参考
- Tannetta D., Collett G., Vatish M., Redman C., Sargent I. Syncytiotrophoblast extracellular vesicles – Circulating biopsies reflecting placental health. Placenta. 2017, 52, 134–138.
- Kristen A., Cadden M. S., Walsh S. W. Neutrophils, but not Lymphocytes or Monocytes, Infi ltrate Maternal Systemic Vasculature in Women with Preeclampsia. Hypertens Pregnancy. 2008, 27(4), 396–405.
- Панова И. А., Кудряшова А. В., Хлипунова Д. А., Смирнова Е. В., Рокотянская Е. А. Характеристика зрелости и адгезионной способности нейтрофилов при преэклампсии. Российский иммунологический журнал. 2014. 8; 3(17), 360–364.
- Delgado-Rizo V., Martínez-Guzmán M. A., IñiguezGutierrez L., García-Orozco A., Alvarado-Navarro A., Fafutis-Morris M. Neutrophil Extracellular Traps and Its Implications in Inflammation: An Overview. Front Immunol. 2017. 8, 81. 5. Schober A. Chemokines in vascular dysfunction and remodeling. Arterios Thromb Vasc Biol. 2008. 28(11), 1950–1959.
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