MOLECULAR MODELLING OF FLAVONOID QUERCETIN TARGETING TO THE TOLL-LIKE RECEPTORS
- Authors: Zaitsev V.G.1, Zheltova A.A.2, Nikonenko A.A.1
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Affiliations:
- Volgograd State University
- Volgograd State Medical University
- Issue: Vol 20, No 2 (2017)
- Pages: 317-319
- Section: Articles
- URL: https://journal-vniispk.ru/1028-7221/article/view/120006
- ID: 120006
Cite item
Abstract
Molecular modelling of quercetin targeting to the extracellular and cytosolic domains of human Tolllike receptors (TLR1-TLR10) was performed. We showed that quercetin can be targeted to various TRLs preferably either in extracellular domain sites (TLR4, TLR5, TLR7, TLR8) or in cytosolic domain sites (TLR1-TLR2, TLR2-TLR6).
About the authors
V. G. Zaitsev
Volgograd State University
Author for correspondence.
Russian Federation
A. A. Zheltova
Volgograd State Medical UniversityRussian Federation
A. A. Nikonenko
Volgograd State UniversityRussian Federation
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