HORIONIC GONADOTROPIN IN REGULATION OF THE FUNCTIONAL ACTIVITY OF T-REGULATORY LYMPHOCYTES
- Authors: Zamorina S.A.1,2
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Affiliations:
- Institute of Ecology and Genetics of Microorganisms UB RAS
- Perm State National Research University
- Issue: Vol 20, No 2 (2017)
- Pages: 319-321
- Section: Articles
- URL: https://journal-vniispk.ru/1028-7221/article/view/120015
- ID: 120015
Cite item
Abstract
The effect of human chorionic gonadotropin (HCG) on apoptosis and production of IL-10 and TGF-β1 by isolated pools of natural T-regulatory lymphocytes (nTreg, CD4+CD25bright) and precursors of adaptive Treg (aTreg, CD4+CD25-) in the in vitro system was studied. As a result, we demonstrated that HCG induces apoptosis of nTreg and interferes with aTreg apoptosis, without affecting the production of IL-10 and TGF-β1 by these cells.
About the authors
S. A. Zamorina
Institute of Ecology and Genetics of Microorganisms UB RAS; Perm State National Research University
Author for correspondence.
Russian Federation
References
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- Заморина С. А., Ширшев С. А. Хорионический гонадотропин - фактор индукции иммунной толерантности при беременности. Иммунология 2013, 34(2), 105-107.
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