CARACTERIZATION OF DISTRIBUTION OF MYELOID-DERIVED SUPPRESSOR CELLS AND MONOCYTES IN DIFFERENT CLINICAL VARIANTS OF ANKYLOSING SPONDYLITIS
- Authors: Morenkova A.Y.1, Tikchonova M.A.1, Sizikov A.E.1, Chumasova O.A.1, Sulutyan A.E.1, Chernykh E.R.1
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Affiliations:
- Federal Budget Institution of Science « Research Institute of Fundamental and Clinical Immunology
- Issue: Vol 22, No 2-1 (2019)
- Pages: 420-422
- Section: ORIGINAL ARTICLES
- URL: https://journal-vniispk.ru/1028-7221/article/view/120235
- DOI: https://doi.org/10.31857/S102872210006917-3
- ID: 120235
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Abstract
The frequencies of myeloid-derived suppressor cell (MDSC) and monocyte subpopulations in patients with ankylosing spondylitis (AS) have been investigated. AS patients, especially with axial disease, had decreased proportion of granulocytic MDSC. In contrast, the frequencies of monocytic MDSC were signifi cantly increased. The proportion of non-classical monocytes was increased in AS patients without peripheral manifestations. Of note, non-classical monocyte levels positively correlated with disease activity.
About the authors
A. Yu. Morenkova
Federal Budget Institution of Science « Research Institute of Fundamental and Clinical Immunology
Author for correspondence.
Email: morenkovasp@yandex.ru
Postgraduate Student, Laboratory of Cellular Immunotherapy,
Novosibirsk
Russian FederationM. A. Tikchonova
Federal Budget Institution of Science « Research Institute of Fundamental and Clinical Immunology
PhD (Biology), Senior Research Associate, Laboratory of Cellular Immunotherapy,
Novosibirsk
Russian FederationA. E. Sizikov
Federal Budget Institution of Science « Research Institute of Fundamental and Clinical Immunology
PhD, Head of Rheumatology Department,
Novosibirsk
Russian FederationO. A. Chumasova
Federal Budget Institution of Science « Research Institute of Fundamental and Clinical Immunology
PhD, rheumatologist, rheumatology department,
Novosibirsk
Russian FederationA. E. Sulutyan
Federal Budget Institution of Science « Research Institute of Fundamental and Clinical Immunology
PhD, rheumatologist, rheumatology department,
Novosibirsk
Russian FederationE. R. Chernykh
Federal Budget Institution of Science « Research Institute of Fundamental and Clinical Immunology
PhD, MD, Professor (Medicine), Corresponding Member, Russian Academy of Sciences, Head, Laboratory of Cellular Immunotherapy,
Novosibirsk
Russian FederationReferences
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