FEATURES OF CYTOKINES, ADIPOKINES, MATRIX MATELOPROTEINASE-9 AND ITS INHIBITORSIMBALANCE, DEPENDING ON THE CLINICAL MANIFESTATIONS OF ATHEROSCLEROSIS

140 patients with coronary atherosclerosis (CA), ischemic heart disease (IHD) and 120 people with obliterating atherosclerosis of lower extremities (OALE) were examined. The levels of IL-1β, IL-6, IFNγ, TNFα, IL-10, TGF-β1, TGF-β2, IL-2, IL-17, soluble cytokine receptors: IL-2R, IL- 6R, TNFα RI and TNFα RII, metalloproteinase-9 and its inhibitors (MMP-9, TIMP-1, MMP-9/TIMP-1, MMP-9/TIMP-2 complexes), adipokines (leptin and adiponectin) in serum. In patients with OALE, increase of IFNγ, TNFα, TN-α RII, IL-6 and TIMP-1 (p<0.05) was registered. By the factor analysis method, it was determined, that the IFNγ, IL-2, TNFα and IL-6 have leading pathogenetic significance in OALE. In patients with IHD, pathogenetic signifi cance and increase of the IL-1β, IL-17 and increase of the leptin was revealed.