Immunity in chronic rhinosinusitis and comorbid conditions
- Authors: Smirnova O.V.1, Sinyakov A.A.1
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Affiliations:
- Research Institute of Medical Problems of the North, Krasnoyarsk Research Center, Siberian Branch, Russian Academy of Sciences
- Issue: Vol 27, No 3 (2024)
- Pages: 635-642
- Section: SHORT COMMUNICATIONS
- URL: https://journal-vniispk.ru/1028-7221/article/view/267534
- DOI: https://doi.org/10.46235/1028-7221-16682-IIC
- ID: 267534
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Abstract
Chronic rhinosinusitis is a disease caused by inflammation of the paranasal sinuses and its mucous membrane with a duration of symptoms of the disease of more than 4 weeks continuously. The purpose of our study was to study the cellular and humoral components of immunity in CRS and comorbid conditions. This study was conducted at the Research Institute of Medical Problems of the North, Krasnoyarsk Research Center, Siberian Branch, Russian Academy of Sciences, Krasnoyarsk, Russian Federation. A total of 91 patients with chronic rhinosinusitis were selected, of which 30 people were patients with isolated chronic rhinosinusitis, 25 people were with chronic rhinosinusitis and deviated nasal septum, 19 people were with chronic rhinosinusitis and chronic rhinitis, and 17 people were with chronic rhinosinusitis and bronchial asthma. The control group consisted of 35 practically healthy blood donors comparable in gender and age to the study groups, who underwent a routine examination at the institute’s clinics. To study systemic cellular immunity in venous blood, flow cytometry was used on a Cytomics FC500 flow cytometer (Beckman Coulter, USA). To stain lymphocytes, monoclonal antibodies (MAbs) were used: CD3+, CD4+, CD8+, CD16+, and CD19+, from Beckman Coulter (USA). With CRS and deviated nasal septum, changes were detected in the form of an increase in the absolute content of B lymphocytes and a decrease in 3 relative synthesis indices. In CRS and chronic rhinitis, an increase in the absolute content of B lymphocytes and a decrease in the relative number of T helper cells and 3 relative synthesis indices were found. In CRS, an increase in the content of B lymphocytes and IgE was detected (but the value was below 100 IU/mL), and a decrease in the relative number of T helper cells and 3 relative synthesis indices. In CRS and bronchial asthma, there was an increase in the absolute content of T helpers, B lymphocytes, hypergammaglobulinemia in classes A and E (more than 100 IU/mL) and a decrease in the relative number of T helper cells, the absolute number of cytotoxic T lymphocytes and 3 relative synthesis indices.
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##article.viewOnOriginalSite##About the authors
O. V. Smirnova
Research Institute of Medical Problems of the North, Krasnoyarsk Research Center, Siberian Branch, Russian Academy of Sciences
Author for correspondence.
Email: ovsmirnova71@mail.ru
PhD, MD (Medicine) Professor, Head, Laboratory of Clinical Pathophysiology
Russian Federation, KrasnoyarskA. A. Sinyakov
Research Institute of Medical Problems of the North, Krasnoyarsk Research Center, Siberian Branch, Russian Academy of Sciences
Email: ovsmirnova71@mail.ru
PhD (Biology), Senior Research Associate, Laboratory of Clinical Pathophysiology
Russian Federation, KrasnoyarskReferences
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