Food sensitization in permanent allergic rhinitis and bronchial asthma
- 作者: Klimov A.V.1, Isaev P.Y.2, Urazova O.I.1, Klimov V.V.1, Denisov A.A.1, Zagreshenko D.S.3, Kukharev Y.V.1, Khudyakova M.I.1, Shkatova A.N.4, Ovcharenko E.V.1, Selezneva O.A.1, Ryzhkova A.Y.1
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隶属关系:
- Siberian State Medical University
- Kanevskaya Central Hospital
- Russian Academy of Continuous Postgraduate Education
- Allergy Unit, Students’ Policlinic
- 期: 卷 28, 编号 3 (2025)
- 页面: 639-644
- 栏目: SHORT COMMUNICATIONS
- URL: https://journal-vniispk.ru/1028-7221/article/view/319913
- DOI: https://doi.org/10.46235/1028-7221-17187-FSI
- ID: 319913
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详细
Atopic allergic diseases (atopies) are recently becoming more common. Despite different sites of allergic inflammation, the sensitizing allergens can show cross-reactive effects, which raises the issues of atopic comorbidity. A combination of allergic rhinitis with food allergies, as well as asthma with food allergies, is becoming more frequent, but still not well understood. The aim of the work was to investigate food sensitization in the permanent allergic rhinitis and asthma and to assess relationships between this conditions and respiratory atopies, due to preferential sensitization to the dust mite Dermatophagoides pteronissinus. The study included 276 patients aged 18-60 years, both males and females, with perennial allergic rhinitis (n = 168) and bronchial asthma (n = 108). We determined blood concentrations of five specific IgE antibodies to food allergens from G8 group, as well as antibodies to the most significant Der p 1 allergen of dust mites Dermatophagoides pteronissinus, which are the leading source of sensitization in respiratory atopies. The data obtained were processed by descriptive statistics taking into account a distribution, calculation of non-parametric criteria, and correlation indexes. All patients were divided into three groups: (1) free of food allergies and sensitization symptoms (46%), (2) with absent clinical manifestations of food allergies, but latent food sensitization (26.1%), and (3) evidence of both symptoms and proven sensitization (27.9%). Thus, food sensitization was found in more than half of the cases of allergic rhinitis and asthma, An expected moderate correlation has been found between antibodies to shrimp and dust mite allergens. No association of IgE to Der p I with other food allergens was revealed. Meanwhile, a significantly higher frequency of clinical food allergies was found in asthma compared to allergic rhinitis. However, when accounting for a sum of subclinical and clinical sensitization, we did not reveal a significant difference between each other. This result may indicate a more reliable maintenance of allergic tolerance against food allergens, or a lack of factors for ceasing the tolerance condition at preclinical stage in allergic rhinitis, as compared to asthma.
作者简介
A. Klimov
Siberian State Medical University
Email: kukharev78@mail.ru
PhD (Medicine), Associate Professor, Department of Immunology and Allergology
俄罗斯联邦, TomskP. Isaev
Kanevskaya Central Hospital
Email: kukharev78@mail.ru
Head
俄罗斯联邦, Kanevskaya village, Krasnodar RegionO. Urazova
Siberian State Medical University
Email: kukharev78@mail.ru
PhD, MD (Medicine), Professor, Corresponding Member, Russian Academy of Sciences, Head, Department of Pathological Physiology
俄罗斯联邦, TomskV. Klimov
Siberian State Medical University
Email: kukharev78@mail.ru
PhD, MD (Medicine), Professor, Head, Department of Immunology and Allergology
俄罗斯联邦, TomskA. Denisov
Siberian State Medical University
Email: kukharev78@mail.ru
PhD, MD (Medicine), Professor, Department of Immunology and Allergology
俄罗斯联邦, TomskD. Zagreshenko
Russian Academy of Continuous Postgraduate Education
Email: kukharev78@mail.ru
PhD (Medicine), Associate Professor, Department of Clinical Laboratory Diagnostics, Novokuznetsk State Institute for Advanced Medical Studies
俄罗斯联邦, NovokuznetskYa. Kukharev
Siberian State Medical University
编辑信件的主要联系方式.
Email: kukharev78@mail.ru
PhD (Medicine), Assistant Professor, Department of Immunology and Allergology
俄罗斯联邦, TomskM. Khudyakova
Siberian State Medical University
Email: kukharev78@mail.ru
Head, Research Center for Shared Equipment Use
俄罗斯联邦, TomskA. Shkatova
Allergy Unit, Students’ Policlinic
Email: kukharev78@mail.ru
PhD (Medicine), MD, Head, Allergy Unit
俄罗斯联邦, TomskE. Ovcharenko
Siberian State Medical University
Email: kukharev78@mail.ru
Laboratory Researcher, Department of Immunology and Allergology
俄罗斯联邦, TomskO. Selezneva
Siberian State Medical University
Email: kukharev78@mail.ru
Student, Pediatric Faculty
俄罗斯联邦, TomskA. Ryzhkova
Siberian State Medical University
Email: kukharev78@mail.ru
ORCID iD: 0000-0002-7862-7992
Student, Medical Biological Faculty
俄罗斯联邦, Tomsk参考
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- Klimov V.V. Textbook of Allergen Tolerance. Cham: Springer, 2022. 325 p.
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