Muc2 KNOCKOUT MICE AS A MODEL FOR TESTING APPROACHES TO ALTER GUT MICROBIOTA
- Authors: Achasova K.M.1,2, Litvinova E.A.2,1
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Affiliations:
- The Federal Research Center Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences
- Siberian Federal Scientific Centre of Agro-BioTechnologies of the Russian Academy of Sciences
- Issue: Vol 22, No 2-2 (2019)
- Pages: 713-715
- Section: ORIGINAL ARTICLES
- URL: https://journal-vniispk.ru/1028-7221/article/view/119404
- DOI: https://doi.org/10.31857/S102872210006753-3
- ID: 119404
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Abstract
Gut is inhabited by numerous of bacteria interacting with the immune system of the host. Disturbance of the gut homeostasis leads to various pathological states, which are to be treated by changing of microbiota. The study demonstrate the effects of microbiota alteration on viability of mice with deficient barrier function in the gut (Muc2-/-). The susceptibility of Muc2-/- mice to changing of microbiota suggesting the mice as an appropriate model for testing approaches to alter gut microbiota.
About the authors
K. M. Achasova
The Federal Research Center Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences;Siberian Federal Scientific Centre of Agro-BioTechnologies of the Russian Academy of Sciences
Author for correspondence.
Email: achasovaks@mail.ru
PhD student in the laboratory of genetics of laboratory animals;
junior researcher in the laboratory for regulation of agricultural animals and plants microbiocenosis,
Novosibirsk
Russian FederationE. A. Litvinova
Siberian Federal Scientific Centre of Agro-BioTechnologies of the Russian Academy of Sciences;The Federal Research Center Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences
Email: fake@neicon.ru
leading researcher in the laboratory for regulation of agricultural animals and plants microbiocenosis;
senior researcher in the laboratory of genetics of laboratory animals,
Novosibirsk
Russian FederationReferences
- Artis D. Epithelial-cell recognition of commensal bacteria and maintenance of immune homeostasis in the gut. // Nat Rev Immunol. – 2008. – V. 8. – N. 6. – P. 411–420. doi: 10.1038/nri2316.
- Johansson M. E., Phillipson M., Petersson J., Velcich A., Holm L., Hansson G. C. The inner of the two Muc2 mucin-dependent mucus layers in colon is devoid of bacteria. // Proc Natl Acad Sci USA. – 2008. – V. 105. – N. 39. – P. 15064–15069. doi: 10.1073/pnas.0803124105.
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