电邮这篇文章 Genetic Predisposition to Cervical Cancer and Prevalence of Oncogenic HPV Types in Female Population of the Republic of Bashkortostan
- 作者: Lenkova K.V.1, Lyalina G.Z.2, Minyazeva R.K.2, Akhmetova V.L.3, Yalaev B.I.4, Gilyazova I.R.1,2, Khusainova R.I.1,4,5, Minniakhmetov I.R.4
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隶属关系:
- Ufa Branch of the Russian Academy of Sciences
- Bashkir State Medical University
- Ufa University of Science and Technology
- Endocrinology Research Centre
- Saint Petersburg State University
- 期: 卷 30, 编号 1 (2025)
- 页面: 5-16
- 栏目: Original Study Articles
- URL: https://journal-vniispk.ru/1028-9984/article/view/313543
- DOI: https://doi.org/10.17816/onco642735
- EDN: https://elibrary.ru/IKCGJW
- ID: 313543
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详细
BACKGROUND: Cervical cancer is a significant medical and social issue that greatly impacts women’s quality of life and life expectancy. The primary pathogenic factor is a persistent infection with a high-risk human papillomavirus (HPV) types.
AIM: The study aimed to evaluate the prevalence and spectrum of HPV infections in the female population of the Republic of Bashkortostan, as well as to determine their molecular and genetic predisposition to cervical cancer.
METHODS: The study included 219 randomly selected HPV-positive samples to evaluate the prevalence and spectrum of HPV types. Four years later, a follow-up screening was conducted in 70 HPV-positive women. The screening included an evaluation of their HPV and cervical statuses, an examination by an obstetrician/gynecologist, cytology, colposcopy, and biopsy for histology when indicated. In the third stage, we compared polymorphisms of the CLPTM1L (rs27069), PAX8 (rs10175462), and CDC42 (rs2268177) genes in patients with histologically confirmed cervical cancer and in apparently healthy women.
RESULTS: No positive correlation was found between the number of HPV types per sample and viral load, nor between viral load and HPV clearance. Genome-wide association studies (GWAS) identified statistically significant associations between cervical cancer risk and the G allele of CLPTM1L rs27069 (χ2 = 4.098; p = 0.043), as well as with the T allele (χ2 = 16.99; p = 3.751e-5) and the TT genotype (χ2 = 17.35; p = 0.0002) of CDC42 rs2268177. No association was found for PAX8 (rs10175462).
CONCLUSION: This was the first Russian study to replicate GWAS results for cervical cancer. Associations were identified for CLPTM1L (rs27069) and CDC42 (rs2268177), but not for PAX8 (rs10175462). The results highlight the need for further research to confirm these associations and improve our understanding of the molecular mechanisms associated with cervical cancer risk and HPV persistence.
作者简介
Ksenia Lenkova
Ufa Branch of the Russian Academy of Sciences
编辑信件的主要联系方式.
Email: ms.kv.kl@mail.ru
ORCID iD: 0000-0001-5903-0085
SPIN 代码: 8509-7901
俄罗斯联邦, Ufa
Gulnara Lyalina
Bashkir State Medical University
Email: davlet_g@mail.ru
ORCID iD: 0000-0001-7540-733X
SPIN 代码: 7602-3416
俄罗斯联邦, Ufa
Raushania Minyazeva
Bashkir State Medical University
Email: dr.gubaydullina@mail.ru
ORCID iD: 0000-0001-5542-9531
SPIN 代码: 9660-0317
俄罗斯联邦, Ufa
Vita Akhmetova
Ufa University of Science and Technology
Email: vita-akh@mail.ru
ORCID iD: 0000-0002-1874-0774
SPIN 代码: 9716-8937
Cand. Sci. (Biology)
俄罗斯联邦, UfaBulat Yalaev
Endocrinology Research Centre
Email: yalaev.bulat@endocrincentr.ru
ORCID iD: 0000-0003-4337-1736
SPIN 代码: 2546-1425
Cand. Sci. (Biology)
俄罗斯联邦, MoscowIrina Gilyazova
Ufa Branch of the Russian Academy of Sciences; Bashkir State Medical University
Email: gilyasova_irina@mail.ru
ORCID iD: 0000-0001-9499-5632
SPIN 代码: 5799-4821
Cand. Sci. (Biology)
俄罗斯联邦, Ufa; UfaRita Khusainova
Ufa Branch of the Russian Academy of Sciences; Endocrinology Research Centre; Saint Petersburg State University
Email: khusainova.rita@endocrincentr.ru
ORCID iD: 0000-0002-8643-850X
SPIN 代码: 4091-9326
Dr. Sci. (Biology)
俄罗斯联邦, Ufa; Moscow; Saint PetersburgIldar Minniakhmetov
Endocrinology Research Centre
Email: minniakhmetov.ildar@endocrincentr.ru
ORCID iD: 0000-0002-7045-8215
SPIN 代码: 8643-7056
Cand. Sci. (Biology)
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