Email this article SIDE EFFECTS OF TWO REGIMENS OF TRIPLE-COMPONENT CHEMOTHERAPY (CAPECITABINE, OXALIPLATIN AND IRINOTECAN) AS FIRST-LINE TREATMENT OF METASTATIC COLORECTAL CANCER
- Authors: Semenov N.N1, Meshcheryakov A.A1
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Affiliations:
- N. N. Blokhin Russian Cancer Research Center under the Russian Academy of Medical Sciences
- Issue: Vol 19, No 3 (2014)
- Pages: 29-31
- Section: Articles
- URL: https://journal-vniispk.ru/1028-9984/article/view/40058
- DOI: https://doi.org/10.17816/onco40058
- ID: 40058
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Abstract
Last ESMO and NCCN recommendations for the treatment of metastatic colorectal cancer include the use of a triple-component chemotherapy. A study of two modes with the inclusion of irinotecan dose of 120 mg/m2 every 2 weeks, oxaliplatin 85 mg/m2 every 2 weeks, the dose of capecitabine 1600 mg/m2/day in 1-7 days with a 1- week break or 1600 mg/m 2 / day in days 1-14 with a 2-week break. Both modes showed satisfactory tolerance without significant gastrointestinal and hematological toxicity. Plan to further study the development of ternary diagrams for the application of the algorithm implementation in a wide oncological practice.
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##article.viewOnOriginalSite##About the authors
N. N Semenov
N. N. Blokhin Russian Cancer Research Center under the Russian Academy of Medical Sciences
Email: niksemenov1969@yandex.ru
д-р мед. наук, ст. научн. сотр. отд-ния химиотерапии и комбинированного лечения злокачественных опухолей 115478, Moscow, Russian Federation
A. A Meshcheryakov
N. N. Blokhin Russian Cancer Research Center under the Russian Academy of Medical Sciences115478, Moscow, Russian Federation
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