Белки семейства клаудинов и их роль в патогенезе и терапии злокачественных новообразований: состояние проблемы и перспективы

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Аннотация

В данном обзоре представлены сведения о белках плотных межклеточных контактов клаудинах и их роли в патогенезе и терапии злокачественных новообразований. Особое внимание уделяется изменениям уровней их экспрессии, а также внутриклеточной локализации в опухолях и прогностической значимости таких изменений при онкологических заболеваниях. Отмечена роль клаудинов в процессе метастазирования, инвазии и устойчивости опухолевых клеток к лекарственной терапии. Также обсуждаются перспективы использования клаудинов в качестве потенциальных мишеней для разработки новых методов диагностики и лечения злокачественных новообразований.

Об авторах

Сергей Васильевич Бойчук

Казанский государственный медицинский университет; Институт фундаментальной медицины и биологии Казанского (Приволжского) федерального университета; Российская медицинская академия непрерывного профессионального образования

Автор, ответственный за переписку.
Email: boichuksergei@mail.ru
ORCID iD: 0000-0003-2415-1084
SPIN-код: 8058-6246

д-р мед. наук, профессор

Россия, Казань; Казань; Москва

Фирюза Фанисовна Бикиниева

Казанский государственный медицинский университет

Email: firuza1995@mail.ru
ORCID iD: 0000-0002-9012-6525
SPIN-код: 9014-1478

канд. мед. наук

Россия, Казань

Павел Борисович Копнин

Национальный медицинский исследовательский центр онкологии им. Н.Н. Блохина

Email: pbkopnin@mail.ru
ORCID iD: 0000-0002-2078-4274
SPIN-код: 2339-5729

канд. биолог. наук

Россия, Москва

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