电邮这篇文章 THE DATA OF DNA- FLOW CYTOMETRY IN PROGNOSIS OF CERVIX CANCER
- 作者: Kravets O.A1, Bogatyrev V.N1
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隶属关系:
- N.N.Blokhin Russian Cancer Research Center of the Russian Academy of Medical Sciences,
- 期: 卷 18, 编号 2 (2013)
- 页面: 31-37
- 栏目: Articles
- URL: https://journal-vniispk.ru/1028-9984/article/view/39977
- DOI: https://doi.org/10.17816/onco39977
- ID: 39977
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The purpose of research - the study of quantitative cell cervical cancer (CC) due to radiation therapy: ploidy and their distribution over the phases of the cell cycle analysis of the relationship of these parameters with clinical prognosis factors. Presents the group of 121 patients with CC II, III, IV stages, where the courses combined radiotherapy were from 2000 to 2008. Biopsy tumor samples were used during the radiotherapy. Diploid tumors were detected in 38 (31.4%) patients, aneuploid - in 75 (62%), tetraploid - in 7 (5.8%) and 1 (0.8%) - gyperaneuploid tumor. Overall and disease free-5-year survival in diploid tumors was higher (68,4 ± 9,6% and 45,1 ± 11,0%) compared to the aneuploid (45,4 ± 8,4% and 32.7 ± 7,2%), p <0.05. Among aneuploid CC recurrence rate is higher than the diploid: 24.0% versus 2.6% (p <0.05), respectively. Aneuploid CC with S phase fraction <7% associated with better overall and disease-free survival within 5 years was 57,2 ± 13,1% and 45,6 ± 11,3%, than those with S-phase fraction 7%- > 14 % - 32,3 ± 10,3% and 18,2 ± 8,5% (p = 0.03 and p = 0.0006), respectively. For S-phase fraction ≥ 14% of all patients died within the 1st year follow-up of disease progression. Similarly, in a group of diploid tumors disease free-5-year survival (p = 0.002) with a low content of cells in S phase was 74,7 ± 10,1% of patients. When S-phase fraction > 7%, all patients died within 3 years of the progression of the disease. With increasing stage of cervical cancer, increased proliferative activity of aneuploid tumors. Disease-free survival was worse with increasing PI (p = 0.01). In patients with cervical cancer stage III - IV at age <49 years, the main prognostic factors include poor differentiated squamous cancer, PI of 15 to 20%, IDNA within 1.1 - 1.84 and more. In patients > 49 years - PI over 20% and IDNA 0.6 - 0.8. In this category of patients the course of chemo-radiotherapy is appropriate. Both ploidy and number of cells in S phase should be seen as independent prognostic criteria in patients with stage II CC.
作者简介
O. Kravets
N.N.Blokhin Russian Cancer Research Center of the Russian Academy of Medical Sciences,
Email: kravetz_olga@mail.ru
д-р мед наук, ст. науч. сотр. отд-ния радиохирургии
V. Bogatyrev
N.N.Blokhin Russian Cancer Research Center of the Russian Academy of Medical Sciences,ведущий научный сотрудник, доктор медицинских наук, профессор.
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