Identification of Specific Genes and Pathways by a Comparative Transcriptomic Study of Hypodermal and Body Muscle Development


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Abstract

The development of diverse tissues may be determined by cell fate at the level of cell lineage, especially for hypodermal (Hyp) and body muscle (BM) development in C. elegans. Here, we focused on hypodermal as well as body muscle development in C. elegans and performed a comparative genome study to explore the gene expression patterns and lineage specific regulatory mechanisms by re-mining the existing treasury. The approach of gene set enrichment analysis on related gene expression profiles was also integrated to mine the significantly associated pathways with tissue-specific transcription factors (TFs) regulation. As a result, we have identified different gene expression patterns as well as some of overlapping and specific genes of each lineage between Hyp and BM development. Furthermore, there were some specific regulatory modules identified for 3 TFs, including 5 pathways for HND-1 such as Hedgehog signaling pathway, 11 pathways for ELT-1 such as Calcium signaling pathway, as well as 23 pathways for NHR-25 such as Jak-STAT signaling pathway and some of metabolic pathways. In conclusion, the identification of specific genes and biological pathways by our comparative transcriptomic study may help us better understand the genetic mechanisms between hypodermal and body muscle development in C. elegans.

About the authors

Xiaoliang Hou

Biological Science and Technology Department, Heilongjiang Vocational College For Nationalities

Author for correspondence.
Email: houxiaoliang126@163.com
China, Harbin, Heilongjiang Province, 150066

Jialin Sun

Biological Science and Technology Department, Heilongjiang Vocational College For Nationalities; Key Laboratory of Forest Plant Ecology, Ministry of Education, Northeast Forestry University

Email: houxiaoliang126@163.com
China, Harbin, Heilongjiang Province, 150066; Harbin, Heilongjiang Province, 150040

Yuqing Wang

School of Life Sciences, Anhui University

Email: houxiaoliang126@163.com
China, Hefei, Anhui Province, 230601

Xude Jiang

Food Engineering Department, Heilongjiang Vocational College For Nationalities

Email: houxiaoliang126@163.com
China, Harbin, Heilongjiang Province, 150066

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