Email this article Peptide Modulators of ASIC Channels of the Sea Anemone Urticina aff. coriacea (Cuvier, 1798) from the Sea of Okhotsk
- Authors: Gladkikh I.N.1, Kvetkina A.N.1, Kostina E.E.2, Kalina R.S.1, Grebnev B.B.1, Koshelev S.G.3, Kozlov S.A.3, Monastyrnaya M.M.1, Kozlovskaya E.P.1
-
Affiliations:
- Elyakov Pacific Institute of Bioorganic Chemistry, Far East Branch, Russian Academy of Sciences
- Zhirmunsky Institute of Marine Biology, National Scientific Center of Marine Biology, Far East Branch, Russian Academy of Sciences
- Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences
- Issue: Vol 44, No 6 (2018)
- Pages: 458-464
- Section: Original Papers
- URL: https://journal-vniispk.ru/1063-0740/article/view/184281
- DOI: https://doi.org/10.1134/S1063074018060044
- ID: 184281
Cite item
Open Access
Access granted
Subscription Access
Abstract
A search for biologically active peptides has been performed in an aqueous extract of the sea anemone Urticina aff. coriacea (Cuvier, 1798) (Actiniidae) from the Sea of Okhotsk. A separation of the peptides by size-exclusion chromatography and subsequent electrophysiological testing have shown that peptides of three fractions can completely inhibit currents of mammalian ASIC1a channels. The sea anemone Urticina aff. coriacea is believed to be a promising source of novel peptides that interact with ASIC channels.
Keywords
About the authors
I. N. Gladkikh
Elyakov Pacific Institute of Bioorganic Chemistry, Far East Branch, Russian Academy of Sciences
Author for correspondence.
Email: irinagladkikh@gmail.com
Russian Federation, Vladivostok, 690022
A. N. Kvetkina
Elyakov Pacific Institute of Bioorganic Chemistry, Far East Branch, Russian Academy of Sciences
Email: irinagladkikh@gmail.com
Russian Federation, Vladivostok, 690022
E. E. Kostina
Zhirmunsky Institute of Marine Biology, National Scientific Center of Marine Biology, Far East Branch,Russian Academy of Sciences
Email: irinagladkikh@gmail.com
Russian Federation, Vladivostok, 690041
R. S. Kalina
Elyakov Pacific Institute of Bioorganic Chemistry, Far East Branch, Russian Academy of Sciences
Email: irinagladkikh@gmail.com
Russian Federation, Vladivostok, 690022
B. B. Grebnev
Elyakov Pacific Institute of Bioorganic Chemistry, Far East Branch, Russian Academy of Sciences
Email: irinagladkikh@gmail.com
Russian Federation, Vladivostok, 690022
S. G. Koshelev
Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences
Email: irinagladkikh@gmail.com
Russian Federation, Moscow, 117997
S. A. Kozlov
Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences
Email: irinagladkikh@gmail.com
Russian Federation, Moscow, 117997
M. M. Monastyrnaya
Elyakov Pacific Institute of Bioorganic Chemistry, Far East Branch, Russian Academy of Sciences
Email: irinagladkikh@gmail.com
Russian Federation, Vladivostok, 690022
E. P. Kozlovskaya
Elyakov Pacific Institute of Bioorganic Chemistry, Far East Branch, Russian Academy of Sciences
Email: irinagladkikh@gmail.com
Russian Federation, Vladivostok, 690022
Supplementary files
