Отправить статью по E-mail Characterization of oligomerization of a peptide from the ebola virus glycoprotein by small-angle neutron scattering
- Авторы: Egorov V.V.1,2, Gorshkov A.N.2, Murugova T.N.3, Vasin A.V.2,4, Lebedev D.V.1, Isaev-Ivanov V.V.1, Kiselev O.I.2
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Учреждения:
- Konstantinov Petersburg Nuclear Physics Institute
- Research Institute of Influenza
- Joint Institute for Nuclear Research
- Institute of Physics, Nanotechnology and Telecommunications
- Выпуск: Том 61, № 1 (2016)
- Страницы: 94-97
- Раздел: Diffraction and Scattering of Neutrons
- URL: https://journal-vniispk.ru/1063-7745/article/view/189638
- DOI: https://doi.org/10.1134/S1063774516010065
- ID: 189638
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Аннотация
Transmission electron microscopy (TEM) and small-angle neutron scattering (SANS) studies showed that model peptides QNALVCGLRQ (G33) and QNALVCGLRG (G31) corresponding to region 551–560 of the GP protein of the Sudan Ebola virus are prone to oligomerization in solution. Both peptides can form amyloid-like fibrills. The G33 peptide forms fibrils within one day of incubation, whereas the fibrillogenesis of the G31 peptide is observed only after incubation for several months. The possible role of the observed processes in the pathogenesis and the possibility of applying a combination of the TEM and SANS techniques to search for new compounds that are able to influence the protein oligomerization are discussed.
Об авторах
V. Egorov
Konstantinov Petersburg Nuclear Physics Institute; Research Institute of Influenza
Автор, ответственный за переписку.
Email: vlaegur@omrb.pnpi.spb.ru
Россия, Orlova Roshcha, Gatchina, Leningrad oblast, 188300; ul. Professora Popova 15/17, St. Petersburg, 197376
A. Gorshkov
Research Institute of Influenza
Email: vlaegur@omrb.pnpi.spb.ru
Россия, ul. Professora Popova 15/17, St. Petersburg, 197376
T. Murugova
Joint Institute for Nuclear Research
Email: vlaegur@omrb.pnpi.spb.ru
Россия, ul. Joliot-Curie 6, Dubna, Moscow region, 141980
A. Vasin
Research Institute of Influenza; Institute of Physics, Nanotechnology and Telecommunications
Email: vlaegur@omrb.pnpi.spb.ru
Россия, ul. Professora Popova 15/17, St. Petersburg, 197376; Politekhnicheskaya ul. 29, St. Petersburg, 195251
D. Lebedev
Konstantinov Petersburg Nuclear Physics Institute
Email: vlaegur@omrb.pnpi.spb.ru
Россия, Orlova Roshcha, Gatchina, Leningrad oblast, 188300
V. Isaev-Ivanov
Konstantinov Petersburg Nuclear Physics Institute
Email: vlaegur@omrb.pnpi.spb.ru
Россия, Orlova Roshcha, Gatchina, Leningrad oblast, 188300
O. Kiselev
Research Institute of Influenza
Email: vlaegur@omrb.pnpi.spb.ru
Россия, ul. Professora Popova 15/17, St. Petersburg, 197376
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