Thermodynamics and kinetics of calcium oxalate crystallization in the presence of amino acids

Abstract

Specific features of the crystallization of calcium oxalates (CaC₂O₄) in the presence of amino acids have been established based on thermodynamic and experimental modeling. Phase formation in the Ca²⁺–C₂O₄^2-–H₂O–amino acid system in a wide range of variation in the component concentrations and solution pH have been theoretically investigated. The influence of pH on the thermodynamic stability of crystallizing compounds is considered. The effect of amino acids of different structures on the formation of the CaC₂O₄ solid phase in a prototype of physiological solution is analyzed. The kinetic crystallization parameters (induction period and rate constant) and crystallite growth are determined.