Crystallization of Calcium Phosphates from the Prototype of Blood Plasma in the Presence of Inorganic and Organic Impurities

Abstract

The crystallization processes in solutions modeling the human blood plasma composition have been investigated. It is revealed that the solid phases consist of OH-deficient water-containing carbonate apatite. The influence of impurities (magnesium and glutamic acid ions) on the crystallization of calcium phosphates is analyzed. The presence of additives in model solution is found to affect the phase composition of samples. The solubility of synthetic samples in solutions of different nature and verapamil preparation is studied. The kinetic characteristics of this process are established, and the dependence of dissolution rate on the experimental laboratory conditions is shown.