Investigation of Nanodrug Phospholipovit by Small-Angle Neutron Scattering

Abstract

The structure of aqueous solutions of the Phospholipovit medicine, intended for transport of water-insoluble molecular drugs, has been investigated by small-angle neutron scattering. Phospholipovit can also be used alone, for example, in case of acute poisoning. When processing experimental data, neutron reflectometry was additionally applied to determine the scattering characteristics of maltose buffer solutions in which the medicine is stored. It is shown that Phospholipovit forms temperature-resistant (in the range of 20–37°C) vesicles of critically small size, with inner radius (~40 Å) comparable with lipid bilayer thickness (~31 Å), in these solutions. The sensitivity of vesicle parameters to an increase in the medicine concentration in solution (up to 25 wt %) and the character of vesicle interaction (indicating the presence of a significant charge on their outer surface) are determined.