Mathematical Modeling of Linear Docking. II. Estimating the Effect of Point Mutations on the Affinity between Protein Molecules
- Авторлар: Koshlan T.V.1, Kulikov K.G.2
-
Мекемелер:
- St. Petersburg State University
- Peter the Great St. Petersburg Polytechnic University
- Шығарылым: Том 63, № 8 (2018)
- Беттер: 1115-1124
- Бөлім: Theoretical and Mathematical Physics
- URL: https://journal-vniispk.ru/1063-7842/article/view/201786
- DOI: https://doi.org/10.1134/S1063784218080091
- ID: 201786
Дәйексөз келтіру
Аннотация
A new method enabling the qualitative determination of the dissociation constant of peptides to full-length proteins and the estimation of the effect of point mutations in peptides on the stability of a formed complex with whole proteins was presented. Based on the developed approach, a qualitative correlation was revealed between the obtained results and the dissociation constant using the formation of a biocomplex of the Bmf, Puma, Bad, Hrk, Bax, Bik, Noxa, Bid, Bim, and Bak BH3-peptides and the Bcl-xl protein and a biocomplex of the Bax BH3-peptides and the Bcl-2 protein with consideration for the replacement of amino acid residues as an example.
Авторлар туралы
T. Koshlan
St. Petersburg State University
Email: kulikov.kirill.g@gmail.com
Ресей, St. Petersburg, 199034
K. Kulikov
Peter the Great St. Petersburg Polytechnic University
Хат алмасуға жауапты Автор.
Email: kulikov.kirill.g@gmail.com
Ресей, St. Petersburg, 195251
Қосымша файлдар
