Comparative Study of Polymer Nanoparticles on the Basis of Caprolactone–Polyvinyl Alcohol Mixtures with an Encapsulated Antitumor Preparation by Atomic Force Microscopy, X-Ray Diffraction, and Dynamic Light Scattering
- Authors: Sukhanova T.E.1,2, Vylegzhanina M.E.1, Volkov A.Y.1, Gasilova E.R.1, Kutin A.A.1, Samy M.3, Abdallah H.M.3, Ayoub M.M.3
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Affiliations:
- Institute of Macromolecular Compounds, Russian Academy of Sciences
- Lebedev Research Institute of Synthetic Rubber
- Department of Polymers and Pigments, National Research Center
- Issue: Vol 64, No 12 (2019)
- Pages: 1729-1737
- Section: 23rd INTERNATIONAL SYMPOSIUM “NANOPHYSICS AND NANOELECTRONICS,” Nizhny Novgorod, March 11–14, 2019
- URL: https://journal-vniispk.ru/1063-7842/article/view/204827
- DOI: https://doi.org/10.1134/S1063784219120235
- ID: 204827
Cite item
Abstract
The morphology, structure, and optical properties of composites with biodegradable polymeric particles, which are based on poly-ε-caprolactone–polyvinyl alcohol (stabilizer) mixtures and contain 5-Fluorouracil (an antitumor preparation), have been studied by atomic-force and optical microscopy, X-ray diffraction, and dynamic and static light scattering. Studies have shown that the morphology of synthesized composites sustains appreciable transformations depending on their stabilizer content. No crystalline reflections corresponding to 5-Fluorouracil have been revealed, thus arguing for a high dispersity of this preparation in the polymeric matrix of caprolactone. The correlations between the structural and morphological parameters, composition, stabilizer concentration and the efficiency of the encapsulation of 5-Fluorouracil by the composites have been established.
About the authors
T. E. Sukhanova
Institute of Macromolecular Compounds, Russian Academy of Sciences; Lebedev Research Institute of Synthetic Rubber
Author for correspondence.
Email: tat_sukhanova@bk.ru
Russian Federation, St. Petersburg, 199004; St. Petersburg, 198035
M. E. Vylegzhanina
Institute of Macromolecular Compounds, Russian Academy of Sciences
Email: tat_sukhanova@bk.ru
Russian Federation, St. Petersburg, 199004
A. Ya. Volkov
Institute of Macromolecular Compounds, Russian Academy of Sciences
Email: tat_sukhanova@bk.ru
Russian Federation, St. Petersburg, 199004
E. R. Gasilova
Institute of Macromolecular Compounds, Russian Academy of Sciences
Email: tat_sukhanova@bk.ru
Russian Federation, St. Petersburg, 199004
A. A. Kutin
Institute of Macromolecular Compounds, Russian Academy of Sciences
Email: tat_sukhanova@bk.ru
Russian Federation, St. Petersburg, 199004
Moshera Samy
Department of Polymers and Pigments, National Research Center
Email: tat_sukhanova@bk.ru
Egypt, Dokki, Giza, Cairo, 12622
Heba M. Abdallah
Department of Polymers and Pigments, National Research Center
Email: tat_sukhanova@bk.ru
Egypt, Dokki, Giza, Cairo, 12622
Magdy M. H. Ayoub
Department of Polymers and Pigments, National Research Center
Email: tat_sukhanova@bk.ru
Egypt, Dokki, Giza, Cairo, 12622
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