Comparative Study of Polymer Nanoparticles on the Basis of Caprolactone–Polyvinyl Alcohol Mixtures with an Encapsulated Antitumor Preparation by Atomic Force Microscopy, X-Ray Diffraction, and Dynamic Light Scattering


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Abstract

The morphology, structure, and optical properties of composites with biodegradable polymeric particles, which are based on poly-ε-caprolactone–polyvinyl alcohol (stabilizer) mixtures and contain 5-Fluorouracil (an antitumor preparation), have been studied by atomic-force and optical microscopy, X-ray diffraction, and dynamic and static light scattering. Studies have shown that the morphology of synthesized composites sustains appreciable transformations depending on their stabilizer content. No crystalline reflections corresponding to 5-Fluorouracil have been revealed, thus arguing for a high dispersity of this preparation in the polymeric matrix of caprolactone. The correlations between the structural and morphological parameters, composition, stabilizer concentration and the efficiency of the encapsulation of 5-Fluorouracil by the composites have been established.

About the authors

T. E. Sukhanova

Institute of Macromolecular Compounds, Russian Academy of Sciences; Lebedev Research Institute of Synthetic Rubber

Author for correspondence.
Email: tat_sukhanova@bk.ru
Russian Federation, St. Petersburg, 199004; St. Petersburg, 198035

M. E. Vylegzhanina

Institute of Macromolecular Compounds, Russian Academy of Sciences

Email: tat_sukhanova@bk.ru
Russian Federation, St. Petersburg, 199004

A. Ya. Volkov

Institute of Macromolecular Compounds, Russian Academy of Sciences

Email: tat_sukhanova@bk.ru
Russian Federation, St. Petersburg, 199004

E. R. Gasilova

Institute of Macromolecular Compounds, Russian Academy of Sciences

Email: tat_sukhanova@bk.ru
Russian Federation, St. Petersburg, 199004

A. A. Kutin

Institute of Macromolecular Compounds, Russian Academy of Sciences

Email: tat_sukhanova@bk.ru
Russian Federation, St. Petersburg, 199004

Moshera Samy

Department of Polymers and Pigments, National Research Center

Email: tat_sukhanova@bk.ru
Egypt, Dokki, Giza, Cairo, 12622

Heba M. Abdallah

Department of Polymers and Pigments, National Research Center

Email: tat_sukhanova@bk.ru
Egypt, Dokki, Giza, Cairo, 12622

Magdy M. H. Ayoub

Department of Polymers and Pigments, National Research Center

Email: tat_sukhanova@bk.ru
Egypt, Dokki, Giza, Cairo, 12622

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