A mass spectrometer for pain-response monitoring in rats

Abstract

A mass spectrometer with a membrane interface has been used for measuring the relative concentration of carbon dioxide (CO₂) released from rat skin in response to thermal irritation and pain stimulus during intraperitoneal propofol–lidocaine anesthesia. It is established that the local anesthetic lidocaine directly influences the central nervous system and induces antinociceptive reaction to thermal irritation.