Analysis of the volatile constituents of Frangula alnus Mill. from Iran


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Abstract

For the first time, the essential oil from the bark of Frangula alnus Mill. was extracted using the hydrodistillation method and examined by gas chromatography equipped with a flame ionization detector and gas chromatography coupled with mass spectrometry. Thirty-one compounds were identified, constituting approximately 94.2% of the oil of F. alnus. The essential oil of F. alnus is rich in oxygenated monoterpenes and oxygenated sesquiterpenes (28.0 and 35.8% of the essential oil, respectively). Nine oxygenated monoterpene and six oxygenated sesquiterpene compounds were identified. The essential oil of F. alnus contains epoxygeranial (6.0%) and geranial (5.5%) (as main oxygenated monoterpenes) and also caryophyllene oxide (17.7%) and spathulenol (11.3) (as main oxygenated sesquiterpenes). Since the essential oil of F. alnus is rich in caryophyllene oxide, it can be used as a preservative in food, drugs, and cosmetics. Importantly, the high content of spathulenol makes the essential oil of F. alnus a good candidate for combination chemotherapy of the multidrug resistance cancer. Spathulenol highly promotes the accumulation of rhodamine123 (substrate of the ATP-binding cassette sub-family B member 1 (ABCB1)) by the multidrug resistance cells, which over-expresses the ABCB1 efflux pump.

About the authors

S. J. Roudbaraki

Department of Chemistry, Arak Branch, Islamic Azad University

Email: nori_ir@yahoo.com
Iran, Islamic Republic of, Arak

D. Nori-Shargh

Department of Chemistry, Arak Branch, Islamic Azad University

Author for correspondence.
Email: nori_ir@yahoo.com
Iran, Islamic Republic of, Arak

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