Отправить статью по E-mail A case of non-monotonous influence of pressure on enantioselectivity in supercritical fluid chromatography
- Авторы: Pokrovskiy O.I.1, Kostenko M.O.2, Lunin V.V.1,2
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Учреждения:
- N. S. Kurnakov Institute of General and Inorganic Chemistry, Russian Academy of Sciences
- Department of Chemistry, M. V. Lomonosov Moscow State University
- Выпуск: Том 66, № 11 (2017)
- Страницы: 2190-2193
- Раздел: Brief Communication
- URL: https://journal-vniispk.ru/1066-5285/article/view/241725
- DOI: https://doi.org/10.1007/s11172-017-2001-7
- ID: 241725
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Аннотация
non-monotonous dependence of selectivity coefficient on pressure in the enantioseparation of salbutamol sulfate by supercritical fluid chromatography was discovered. When increasing the isothermal pressure of the mobile phase in the interval 100—200 bar at a temperature of 20 °С, the selectivity coefficient of separation of salbutamol enantiomers first increased, then decreased, followed by another increase. Such a behavior is atypical and determines the expediency of using pressure to control selectivity in this kind of chromatography.
Об авторах
O. Pokrovskiy
N. S. Kurnakov Institute of General and Inorganic Chemistry, Russian Academy of Sciences
Автор, ответственный за переписку.
Email: oleg.pokrovskiy@supercritical.ru
Россия, 31 Leninsky prosp., Moscow, 119991
M. Kostenko
Department of Chemistry, M. V. Lomonosov Moscow State University
Email: oleg.pokrovskiy@supercritical.ru
Россия, Build. 3, 1 Leninskie Gory, Moscow, 119991
V. Lunin
N. S. Kurnakov Institute of General and Inorganic Chemistry, Russian Academy of Sciences; Department of Chemistry, M. V. Lomonosov Moscow State University
Email: oleg.pokrovskiy@supercritical.ru
Россия, 31 Leninsky prosp., Moscow, 119991; Build. 3, 1 Leninskie Gory, Moscow, 119991
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