Experimental study of the antitumor effect of aurumacryl
- Авторлар: Ostrovskaya L.A.1, Korman D.B.1, Grehova A.K.1, Osipov A.N.2, Bluhterova N.V.1, Fomina M.M.1, Rikova V.A.1, Abzaeva K.A.3
- 
							Мекемелер: 
							- N. M. Emanuel Institute of Biochemical Physics, Russian Academy of Sciences
- A. I. Burnazyan Federal Medical Biophysical Center, Federal Medical-Biological Agency
- A. E. Favorsky Irkutsk Institute of Chemistry, Siberian Branch of the Russian Academy of Sciences
 
- Шығарылым: Том 66, № 12 (2017)
- Беттер: 2333-2338
- Бөлім: Full Article
- URL: https://journal-vniispk.ru/1066-5285/article/view/241870
- DOI: https://doi.org/10.1007/s11172-017-2025-z
- ID: 241870
Дәйексөз келтіру
Аннотация
Gold polyacrylate (aurumacryl) belonging to a new class of compounds for oncology — metal polyacrylates — was shown to exhibit strong antitumor activity. Aurumacryl causes 80—90% growth inhibition in vivo of murine solid tumors (Lewis lung carcinoma, Ca-755 adenocarcinoma, and Acatol adenocarcinoma) compared to the control and induces cell death in vitro in 60% of MCF-7 human breast carcinoma cells. Substantial changes in proliferation kinetics of the surviving fraction of tumor cells following treatment with aurumacryl were observed, which are related to the predominant accumulation (93%) of cells in the proliferative resting phase G0 and a substantial decrease in the percentage of proliferating cells (7%). These data provide evidence that the cells that survive lose reproductive ability under treatment with aurumacryl.
Авторлар туралы
L. Ostrovskaya
N. M. Emanuel Institute of Biochemical Physics, Russian Academy of Sciences
							Хат алмасуға жауапты Автор.
							Email: larros@list.ru
				                					                																			                												                	Ресей, 							4 ul. Kosygina, Moscow, 119334						
D. Korman
N. M. Emanuel Institute of Biochemical Physics, Russian Academy of Sciences
														Email: larros@list.ru
				                					                																			                												                	Ресей, 							4 ul. Kosygina, Moscow, 119334						
A. Grehova
N. M. Emanuel Institute of Biochemical Physics, Russian Academy of Sciences
														Email: larros@list.ru
				                					                																			                												                	Ресей, 							4 ul. Kosygina, Moscow, 119334						
A. Osipov
A. I. Burnazyan Federal Medical Biophysical Center, Federal Medical-Biological Agency
														Email: larros@list.ru
				                					                																			                												                	Ресей, 							46 ul. Zhivopisnaya, Moscow, 123098						
N. Bluhterova
N. M. Emanuel Institute of Biochemical Physics, Russian Academy of Sciences
														Email: larros@list.ru
				                					                																			                												                	Ресей, 							4 ul. Kosygina, Moscow, 119334						
M. Fomina
N. M. Emanuel Institute of Biochemical Physics, Russian Academy of Sciences
														Email: larros@list.ru
				                					                																			                												                	Ресей, 							4 ul. Kosygina, Moscow, 119334						
V. Rikova
N. M. Emanuel Institute of Biochemical Physics, Russian Academy of Sciences
														Email: larros@list.ru
				                					                																			                												                	Ресей, 							4 ul. Kosygina, Moscow, 119334						
K. Abzaeva
A. E. Favorsky Irkutsk Institute of Chemistry, Siberian Branch of the Russian Academy of Sciences
														Email: larros@list.ru
				                					                																			                												                	Ресей, 							1 ul. Favorskogo, Irkutsk, 664033						
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