Email this article Xymedon conjugate with biogenic acids. Antioxidant properties of a conjugate of Xymedon with l-ascorbic acid
- Authors: Vyshtakalyuk A.B.1, Semenov V.E.1,2, Sudakov I.A.2, Bushmeleva K.N.2, Gumarova L.F.1, Parfenov A.A.1,2, Nazarov N.G.1,3, Galyametdinova I.V.1, Zobov V.V.1,3
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Affiliations:
- A. E. Arbuzov Institute of Organic and Physical Chemistry, Kazan Scientific Center, Russian Academy of Sciences
- Kazan National Research Technological University
- Kazan Federal University
- Issue: Vol 67, No 4 (2018)
- Pages: 705-711
- Section: Full Article
- URL: https://journal-vniispk.ru/1066-5285/article/view/242442
- DOI: https://doi.org/10.1007/s11172-018-2126-3
- ID: 242442
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Abstract
Antiradical activity and antioxidant properties of a conjugate of Xymedon with l-ascorbic acid were studied. In contrast to Xymedon, a conjugate of Xymedon with l-ascorbic acid was found to react with free radicals. Pro-oxidant activity of the conjugate of Xymedon with l-ascorbic acid in a chemiluminescence system is weaker as compared to individual l-ascorbic acid. This is the evidence of the increase in the stability of ascorbic acid upon conjugation with a molecule of Xymedon. Conjugate of Xymedon with l-ascorbic acid facilitates the decrease in the concentration of a lipid peroxidation product (malondialdehyde) and the activity of superoxide dismutase in liver and serum of laboratory animals exposed to intoxication with a known hepatotropic toxin CCl4. This observation shows the contribution of the antioxidant action to the hepatoprotective effect of the studied Xymedon derivative.
About the authors
A. B. Vyshtakalyuk
A. E. Arbuzov Institute of Organic and Physical Chemistry, Kazan Scientific Center, Russian Academy of Sciences
Author for correspondence.
Email: alex.vysh@mail.ru
Russian Federation, 8 ul. Acad. Arbuzova, Kazan, Russian Federation, 420088
V. E. Semenov
A. E. Arbuzov Institute of Organic and Physical Chemistry, Kazan Scientific Center, Russian Academy of Sciences; Kazan National Research Technological University
Email: alex.vysh@mail.ru
Russian Federation, 8 ul. Acad. Arbuzova, Kazan, Russian Federation, 420088; 68 ul. K. Marksa, Kazan, Russian Federation, 420015
I. A. Sudakov
Kazan National Research Technological University
Email: alex.vysh@mail.ru
Russian Federation, 68 ul. K. Marksa, Kazan, Russian Federation, 420015
K. N. Bushmeleva
Kazan National Research Technological University
Email: alex.vysh@mail.ru
Russian Federation, 68 ul. K. Marksa, Kazan, Russian Federation, 420015
L. F. Gumarova
A. E. Arbuzov Institute of Organic and Physical Chemistry, Kazan Scientific Center, Russian Academy of Sciences
Email: alex.vysh@mail.ru
Russian Federation, 8 ul. Acad. Arbuzova, Kazan, Russian Federation, 420088
A. A. Parfenov
A. E. Arbuzov Institute of Organic and Physical Chemistry, Kazan Scientific Center, Russian Academy of Sciences; Kazan National Research Technological University
Email: alex.vysh@mail.ru
Russian Federation, 8 ul. Acad. Arbuzova, Kazan, Russian Federation, 420088; 68 ul. K. Marksa, Kazan, Russian Federation, 420015
N. G. Nazarov
A. E. Arbuzov Institute of Organic and Physical Chemistry, Kazan Scientific Center, Russian Academy of Sciences; Kazan Federal University
Email: alex.vysh@mail.ru
Russian Federation, 8 ul. Acad. Arbuzova, Kazan, Russian Federation, 420088; 5 ul. Tovarishcheskaya, Kazan, Russian Federation, 420097
I. V. Galyametdinova
A. E. Arbuzov Institute of Organic and Physical Chemistry, Kazan Scientific Center, Russian Academy of Sciences
Email: alex.vysh@mail.ru
Russian Federation, 8 ul. Acad. Arbuzova, Kazan, Russian Federation, 420088
V. V. Zobov
A. E. Arbuzov Institute of Organic and Physical Chemistry, Kazan Scientific Center, Russian Academy of Sciences; Kazan Federal University
Email: alex.vysh@mail.ru
Russian Federation, 8 ul. Acad. Arbuzova, Kazan, Russian Federation, 420088; 5 ul. Tovarishcheskaya, Kazan, Russian Federation, 420097
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