Отправить статью по E-mail Multicomponent reactions in the synthesis of dihydropyrimidine-containing podands having tuberculostatic activity
- Авторы: Fedorova O.V.1, Filatova E.S.1,2, Titova Y.A.1, Kravchenko M.A.3, Medvinskiy I.D.3, Rusinov G.L.1,2, Charushin V.N.1,2
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Учреждения:
- Postovsky Institute of Organic Synthesis, Ural Branch of the Russian Academy of Sciences
- Ural Federal University named after the first President of Russia B. N. Yeltsin
- Ural Research Institute of Phthisiopulmonology, Ministry of Health of the Russian Federation
- Выпуск: Том 67, № 4 (2018)
- Страницы: 743-746
- Раздел: Full Article
- URL: https://journal-vniispk.ru/1066-5285/article/view/242459
- DOI: https://doi.org/10.1007/s11172-018-2131-6
- ID: 242459
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Аннотация
Dihydropyrimidinethione podands, as well as podands containing 2-thienyl substituents have been synthesized via the multicomponent Biginelli reaction. Tuberculostatic activity of the novel podands was shown to depend on the polyether unit length. In particular, activity of dihydropyrimidinethione podands against laboratory strains of Mycobacterium tuberculosis, H37Rv, M. avium, M. terrae, and the clinical strain of multi-drug resistant M. tuberculosis (MDR), increases with a shortening of the polyether unit length.
Об авторах
O. Fedorova
Postovsky Institute of Organic Synthesis, Ural Branch of the Russian Academy of Sciences
Email: sintonin@mail.ru
Россия, 22 S. Kovalevskoi ul., Ekaterinburg, Russian Federation, 620990
E. Filatova
Postovsky Institute of Organic Synthesis, Ural Branch of the Russian Academy of Sciences; Ural Federal University named after the first President of Russia B. N. Yeltsin
Автор, ответственный за переписку.
Email: sintonin@mail.ru
Россия, 22 S. Kovalevskoi ul., Ekaterinburg, Russian Federation, 620990; 19 Mira ul., Ekaterinburg, Russian Federation, 620002
Yu. Titova
Postovsky Institute of Organic Synthesis, Ural Branch of the Russian Academy of Sciences
Email: sintonin@mail.ru
Россия, 22 S. Kovalevskoi ul., Ekaterinburg, Russian Federation, 620990
M. Kravchenko
Ural Research Institute of Phthisiopulmonology, Ministry of Health of the Russian Federation
Email: sintonin@mail.ru
Россия, 50 XXII Partsyezda ul., Ekaterinburg, Russian Federation, 620039
I. Medvinskiy
Ural Research Institute of Phthisiopulmonology, Ministry of Health of the Russian Federation
Email: sintonin@mail.ru
Россия, 50 XXII Partsyezda ul., Ekaterinburg, Russian Federation, 620039
G. Rusinov
Postovsky Institute of Organic Synthesis, Ural Branch of the Russian Academy of Sciences; Ural Federal University named after the first President of Russia B. N. Yeltsin
Email: sintonin@mail.ru
Россия, 22 S. Kovalevskoi ul., Ekaterinburg, Russian Federation, 620990; 19 Mira ul., Ekaterinburg, Russian Federation, 620002
V. Charushin
Postovsky Institute of Organic Synthesis, Ural Branch of the Russian Academy of Sciences; Ural Federal University named after the first President of Russia B. N. Yeltsin
Email: sintonin@mail.ru
Россия, 22 S. Kovalevskoi ul., Ekaterinburg, Russian Federation, 620990; 19 Mira ul., Ekaterinburg, Russian Federation, 620002
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