Lactamomethyl derivatives of diphenols: synthesis, structure, and potential biological activity

Vad. V. Negrebetsky; S. V. Vorobyev; E. P. Kramarova; A. G. Shipov; T. A. Shmigol; Yu. I. Baukov; A. A. Lagunin; A. A. Korlyukov; D. E. Arkhipov

doi:10.1007/s11172-018-2250-0

Lactamomethyl derivatives of diphenols: synthesis, structure, and potential biological activity

Autores: Negrebetsky V.V.¹^,2, Vorobyev S.V.¹^,2, Kramarova E.P.¹^,2, Shipov A.G.¹^,2, Shmigol T.A.¹^,2, Baukov Y.I.¹^,2, Lagunin A.A.¹^,3, Korlyukov A.A.⁴, Arkhipov D.E.⁴
Afiliações:
1. N. I. Pirogov Russian National Research Medical University
2. Department of Medical Chemistry and Toxicology
3. Department of Bioinformatics
4. A. N. Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences
Edição: Volume 67, Nº 8 (2018)
Páginas: 1518-1529
Seção: Article
URL: https://journal-vniispk.ru/1066-5285/article/view/242892
DOI: https://doi.org/10.1007/s11172-018-2250-0
ID: 242892

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Resumo

A series of mono-, bis-, and tris-substituted lactamomethyl derivatives of diphenols were synthesized. The solution and solid-state structures of these compounds were confirmed by IR and NMR spectroscopy and X-ray diffraction. The in silico evaluation indicated a high probability that these compounds have various biological activities.

Sobre autores

Vad. Negrebetsky

N. I. Pirogov Russian National Research Medical University; Department of Medical Chemistry and Toxicology