The distribution of complexes  69m ZnL 1 Cl 2 , [ 69m Zn(L 2 ) 2 ]Cl 2 , and [ 69m Zn(L 2 ) 2 ]Sal 2  (L 1  is  N -(5,6-dihydro-4 H -1,3-thiazin-2-yl)benzamide, L 2  is 2-aminopyrimidine, Sal is a salicylate ion)  in vivo  in mice

M. A. Orlova; T. P. Trofimova; G. Yu. Aleshin; S. S. Belyshev; A. P. Orlov

doi:10.1007/s11172-018-2254-9

The distribution of complexes ^69mZnL¹Cl₂, [^69mZn(L²)₂]Cl₂, and [^69mZn(L²)₂]Sal₂ (L¹ is N-(5,6-dihydro-4H-1,3-thiazin-2-yl)benzamide, L² is 2-aminopyrimidine, Sal is a salicylate ion) in vivo in mice

作者: Orlova M.A.¹^,2, Trofimova T.P.¹^,3, Aleshin G.Y.¹, Belyshev S.S.⁴, Orlov A.P.¹
隶属关系:
1. Department of Chemistry, M. V. Lomonosov Moscow State University
2. D. Rogachev National Medical Research Center of Pediatric Hematology, Oncology, and Immunology
3. Institute of Physiologically Active Compounds, Russian Academy of Sciences
4. Skobel’tsyn Research Institute of Nuclear Physics, M. V. Lomonosov Moscow State University
期: 卷 67, 编号 8 (2018)
页面: 1542-1543
栏目: Article
URL: https://journal-vniispk.ru/1066-5285/article/view/242920
DOI: https://doi.org/10.1007/s11172-018-2254-9
ID: 242920

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The distribution of complexes of thiazine and pyrimidine derivatives possessing antileukemic activity and labeled with radionuclide ^69mZn in the organs of mice and its rate of excretion were studied. A solution of ZnCl₂ was used for comparison. An increase in the time of excretion of the drug from the body and a decrease of its penetration into the brain in the presence of a salicylate ion were observed.

作者简介

M. Orlova

Department of Chemistry, M. V. Lomonosov Moscow State University; D. Rogachev National Medical Research Center of Pediatric Hematology, Oncology, and Immunology

编辑信件的主要联系方式.
Email: orlova.radiochem@mail.ru
俄罗斯联邦, Build. 3, 1 Leninskie Gory, Moscow, 119991; 1 ul. Samory Mashela, Moscow, 117997

T. Trofimova

Department of Chemistry, M. V. Lomonosov Moscow State University; Institute of Physiologically Active Compounds, Russian Academy of Sciences

Email: orlova.radiochem@mail.ru
俄罗斯联邦, Build. 3, 1 Leninskie Gory, Moscow, 119991; 1 Severnyi pr-d, Chernogolovka, Moscow Region, 142432

G. Aleshin

Department of Chemistry, M. V. Lomonosov Moscow State University

Email: orlova.radiochem@mail.ru
俄罗斯联邦, Build. 3, 1 Leninskie Gory, Moscow, 119991

S. Belyshev

Skobel’tsyn Research Institute of Nuclear Physics, M. V. Lomonosov Moscow State University

Email: orlova.radiochem@mail.ru
俄罗斯联邦, Build. 19, 1 Leninskie Gory, Moscow, 119991

A. Orlov