A convenient synthesise of 3,4-dihydro-2H-thiopyran-2,3-dicarboxylic acid derivatives

Resumo

A three-component one-pot procedure to synthesize 2,4-disubstituted b-fused 3,4-dihydro-2H-thiopyran derivatives by the Diels—Alder reaction of the in situ generated α,β-enethiones with maleic acid derivatives was developed. The reactivity of different unsaturated thioketones as dienes and maleic acid derivatives as dienophiles under the developed reaction conditions was studied.