Reactions of 4-aryl- N -hetaryl-2-hydroxy-4-oxobut-2-enamides with hydroxylamine and biological activity of the products

N. A. Pulina; F. V. Sobin; T. A. Yushkova; V. V. Novikova

doi:10.1007/s11172-019-2466-7

Reactions of 4-aryl-N-hetaryl-2-hydroxy-4-oxobut-2-enamides with hydroxylamine and biological activity of the products

Authors: Pulina N.A.¹, Sobin F.V.¹, Yushkova T.A.¹, Novikova V.V.¹
Affiliations:
1. Perm State Pharmaceutical Academy, Ministry of Health of the Russian Federation
Issue: Vol 68, No 3 (2019)
Pages: 628-633
Section: Full Article
URL: https://journal-vniispk.ru/1066-5285/article/view/243327
DOI: https://doi.org/10.1007/s11172-019-2466-7
ID: 243327

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Abstract

The reactions of 4-aryl-N-hetaryl-2-hydroxy-4-oxobut-2-enamides (hetaryl is 2-pyridyl, 2-azolyls, benzo[d]thiazol-2-yl) with hydroxylamine yielded 4-aryl-N-hetaryl-2-hydroxyimino-4-oxobutanamides and 5-aryl-N-hetarylisoxazole-3-carboxamides. The products were searched for representatives with high antimicrobial and anti-inflammatory activities and low acute toxicity. A structure—pharmacological activity relationship of the prepared compounds was established.