Email this article Synthesis and antiviral activity of 1-hydroxy-2-(2-hydroxyphenyl)imidazoles against vaccinia virus
- Authors: Nikitina P.A.1,2, Bormotov N.I.3, Shishkina L.N.3, Tikhonov A.Y.4, Perevalov V.P.1
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Affiliations:
- D. I. Mendeleev University of Chemical Technology of Russia
- A. N. Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences
- State Research Center of Virology and Biotechnology VECTOR
- N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch of the Russian Academy of Sciences
- Issue: Vol 68, No 3 (2019)
- Pages: 634-637
- Section: Full Article
- URL: https://journal-vniispk.ru/1066-5285/article/view/243328
- DOI: https://doi.org/10.1007/s11172-019-2467-6
- ID: 243328
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Abstract
2-(2-Hydroxyplienyl)imidazole derivatives were synthesized and tested for antiviral activity against vaccinia virus in Vero cell culture. 1-Methylimidazole 3-oxides, 1-methoxyimidazoles, and 1H-imidazoles showed no activity, whereas some 1-hydroxyimidazole derivatives hold promise, exhibiting antiviral activity and weak cytotoxicity.
About the authors
P. A. Nikitina
D. I. Mendeleev University of Chemical Technology of Russia; A. N. Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences
Author for correspondence.
Email: polinandrevna@yandex.ru
Russian Federation, 9 pl. Miusskaya, Moscow, 125047; 28 ul. Vavilova, Moscow, 119991
N. I. Bormotov
State Research Center of Virology and Biotechnology VECTOR
Email: polinandrevna@yandex.ru
Russian Federation, Koltsovo, Novosibirsk Region, 630559
L. N. Shishkina
State Research Center of Virology and Biotechnology VECTOR
Email: polinandrevna@yandex.ru
Russian Federation, Koltsovo, Novosibirsk Region, 630559
A. Ya. Tikhonov
N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch of the Russian Academy of Sciences
Email: polinandrevna@yandex.ru
Russian Federation, 9 prosp. Akad. Lavrentieva, Novosibirsk, 630090
V. P. Perevalov
D. I. Mendeleev University of Chemical Technology of Russia
Email: polinandrevna@yandex.ru
Russian Federation, 9 pl. Miusskaya, Moscow, 125047
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