Specific properties of hydroxyapatite as a potential transporter of copper ions and its complexes
- 作者: Orlova M.A.1,2,3, Nikolaev A.L.1, Trofimova T.P.1,4, Severin A.V.1, Gopin A.V.1, Zolotova N.S.1, Dolgova V.K.1, Orlov A.P.1
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隶属关系:
- Chemical Department, M. V. Lomonosov Moscow State University
- Department of Biochemistry and Pharmacology, Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology
- Medical Faculty, N. I. Pirogov Russian National Research Medical University
- Institute of Physiologically Active Compounds, Russian Academy of Sciences
- 期: 卷 68, 编号 5 (2019)
- 页面: 1102-1108
- 栏目: Full Article
- URL: https://journal-vniispk.ru/1066-5285/article/view/243387
- DOI: https://doi.org/10.1007/s11172-019-2526-z
- ID: 243387
如何引用文章
详细
Modification of the cocrystallization method for producing hydroxyapatite (HAP) and an HAP-Cu combination to the enzymatic method using alkaline phosphatase leads to a change in the morphology, sizes, sorption capacity, type of particles, and conformity with the Langmuir and Freundlich models. A positive factor of the enzyme usage is an increase in the sorption capacity and the possibility to strictly control the particle sizes depending on the concentration of the enzyme used. The L2CuCl4 complex was synthesized on the basis of 2-aminopyrimidine (L), which is the precursor of many anticancer drugs, and the possibilities of introducing L2CuCl4 into the HAP composite were considered. The cytotoxicity data for various HAP and L2CuCl4 composites with respect to various types of leukemic cells as compared to lymphocytes of healthy donors showed antileukemic activity of the copper complex and the absence of HAP cytotoxicity in a wide range of concentrations.
作者简介
M. Orlova
Chemical Department, M. V. Lomonosov Moscow State University; Department of Biochemistry and Pharmacology, Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology; Medical Faculty, N. I. Pirogov Russian National Research Medical University
编辑信件的主要联系方式.
Email: orlova.radiochem@mail.ru
俄罗斯联邦, Building 3, 1 Leninskie Gory, Moscow, 119991; 1 ul. Samory Mashela, Moscow, 117997; 1 ul. Ostrovityanova, Moscow, 117997
A. Nikolaev
Chemical Department, M. V. Lomonosov Moscow State University
Email: orlova.radiochem@mail.ru
俄罗斯联邦, Building 3, 1 Leninskie Gory, Moscow, 119991
T. Trofimova
Chemical Department, M. V. Lomonosov Moscow State University; Institute of Physiologically Active Compounds, Russian Academy of Sciences
Email: orlova.radiochem@mail.ru
俄罗斯联邦, Building 3, 1 Leninskie Gory, Moscow, 119991; 1 Severnyi proezd, Chernogolovka, Moscow Region, 142432
A. Severin
Chemical Department, M. V. Lomonosov Moscow State University
Email: orlova.radiochem@mail.ru
俄罗斯联邦, Building 3, 1 Leninskie Gory, Moscow, 119991
A. Gopin
Chemical Department, M. V. Lomonosov Moscow State University
Email: orlova.radiochem@mail.ru
俄罗斯联邦, Building 3, 1 Leninskie Gory, Moscow, 119991
N. Zolotova
Chemical Department, M. V. Lomonosov Moscow State University
Email: orlova.radiochem@mail.ru
俄罗斯联邦, Building 3, 1 Leninskie Gory, Moscow, 119991
V. Dolgova
Chemical Department, M. V. Lomonosov Moscow State University
Email: orlova.radiochem@mail.ru
俄罗斯联邦, Building 3, 1 Leninskie Gory, Moscow, 119991
A. Orlov
Chemical Department, M. V. Lomonosov Moscow State University
Email: orlova.radiochem@mail.ru
俄罗斯联邦, Building 3, 1 Leninskie Gory, Moscow, 119991
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